RGPV / RGTU B Pharma, PHARMACY 4th (IV) Semester PY 405 Pharmacology-I syllabus (Practical)

Tags: RGPV, B Pharma, PHARMACY syllabus, PY - 405 Pharmacology-I syllabus (Practical), B. Pharmacy, IV Semester syllabus, BPharma 4th Semester syllabus, RGPV PY 401 syllabus

Rajiv Gandhi Technological University, Bhopal (MP)
BPharma BRANCH: PHARMACY FOURTH IV SEMESTER
PY - 405 Pharmacology-I (Practical)

Related: PY - 405 Pharmacology-I (Theory)

V-P-1 PHARMACOLOGY I PRACTICALS

List of practicals:
1. Introduction to Experimental Pharmacology and various regulatory authorities.
2. Study of common laboratory animals and anesthetics used in animal studies.
3. Study of various routes of drug administration in experimental animals.
4. Preparation of various physiological salt solution and set up of isolated rat ileum preparation.
5. Study the effects of various agonists and antagonists on isolated rat ileum preparation.
6. Plot dose response curve of choline using isolated gunea pig ileum preparation.
7. Plot dose response curve of histamine using isolated guinea pig ileum preparation.
8. Study the effect of autonomic drugs mydriatic and miotic on rabbit eye.
9. Study the effect of local anesthetics on rabbit eye.
10. Study the peripheral analgesic activity of indomethacin using writhing test on mice.
11. Study anti- inflammatory activity of indomethacin using rat paw edema paradigm.
12. Study the neuromuscular effect of d-tubocurarine/ succinyl choline using rotarod apparatus.

Books recommended
1. Hardmen, J.G., Limbired, L.E., Molinoss, P.B., Ruddon, R.W. and Gil, A.G., Goodman and Gillman’s The Pharmacological basis of Therapeutics, Pergamon Press.
2. Satoskar, R.S. and Bhandarkar, S.D., Pharmacology and Pharmacotherapeutics.
3. Tripathi, K.D., Essentials of Medical Pharmcology.
4. Kulkarni, S.K., Handbook of Experimental Pharmacology, Vallabh Prakashan, New Delhi.
5. Crossland, J and Thomson, J.H., Essential of Pharmacology, Harper and Row, Publishers, New York.
6. Craig, C.R. and Stitzel, R.R., Modern Pharmacology, Little Brown and Company.
7. Rang, M.P. , Dale, M.M. and Riter, J.M., Pharmacology, Churchill Livingstone.
8. Paul, L., Principles of Pharmacology, Chamman and Hall.
9. Herfindal, E.T. and Hirschman, J.L., Clinical Pharmacy and Therapeutics, William and Wilkins. Katzung, B.G., Basic and Clinical Pharmacology, Prentice Hall International.

RGPV / RGTU B Pharma, PHARMACY 4th (IV) Semester PY 405 Pharmacology-I (Theory) syllabus

Tags: RGPV, B Pharma, PHARMACY syllabus, PY - 405 Pharmacology-I syllabus (THEORY), B. Pharmacy, IV Semester syllabus, BPharma 4th Semester syllabus, RGPV PY 401 syllabus

Rajiv Gandhi Technological University, Bhopal (MP)
BPharma BRANCH: PHARMACY FOURTH IV SEMESTER
PY - 405 Pharmacology-I (Theory)

General Pharmacology

a.) Introduction to pharmacology, sources of drugs, dosage forms and routes of administration, mechanism of action, combined effects of drugs, factors modifying drug action, tolerance and dependence, pharmacogenetics.
b.) Absorption, distribution and excretion of drugs, principle of basic and clinical pharmacokinetics adverse drug reactions and treatment of poisoning, ADME drug interaction, bioassay of drugs and biological standardization, discovery and development of new drugs. Introduction to clinical trials.

Pharmacology of Peripheral Nervous System
a. Neurohumoral transmission (autonomous and somatic)
b. Parasympathomimetic, parasympatholytic, sympathomimetics, sympatholytics, neuron blocking agents.
c. Neuromuscular blocking agents
d. Local anaesthetic agents

Autocoids
a. Histamine, bradykinin 5- HT and their antagonists.
b. Prostaglandins, leukotrienes and platelet activating factors.

Analgesic, Antipyretic, Anti-inflammatory and Anti-Gout Drugs:
Drugs acting on Respiratory System and Pathophysiology of respiratory system:
a. Anti-asthmatic drugs including bronchodilators
b. Anti-tussives and expectorants

Books Recommended:
1. Satoskar, R.S. and Bhandarkar, S.D., Pharmacology and Pharmacotherapeutics.
2. Tripathi, K.D., Essentials of Medical Pharmcology.
3. Kulkarni, S.K., Handbook of Experimental Pharmacology, Vallabh Prakashan, New Delhi.
4. Crossland, J and Thomson, J.H., Essential of Pharmacology, Harper and Row, Publishers, New York.
5. Craig, C.R. and Stitzel, R.R., Modern Pharmacology, Little Brown and Company.
6. Rang, M.P. , Dale, M.M. and Riter, J.M., Pharmacology, Churchill Livingstone.
7. Paul, L., Principles of Pharmacology, Chamman and Hall.
8. Herfindal, E.T. and Hirschman, J.L., Clinical Pharmacy and Therapeutics, William and Wilkins.
9. Katzung, B.G., Basic and Clinical Pharmacology, Prentice Hall International.

PY 405 Pharmacology-I - Practical
V-P-1 PHARMACOLOGY I PRACTICALS

RGPV / RGTU B Pharma, PHARMACY 4th (IV) Semester PY 404 PHARMACEUTICAL CHEMISTRY-V (BIOCHEMISTRY) syllabus Theory

Tags: RGPV, B Pharma, PHARMACY syllabus, PY 404 PHARMACEUTICAL CHEMISTRY-V (BIOCHEMISTRY) PRACTICAL syllabus , B. Pharmacy, IV Semester syllabus, BPharma 4th Semester syllabus, RGPV PY 401 syllabus

Rajiv Gandhi Technological University, Bhopal (MP)
BRANCH: BPharma, PHARMACY FOURTH IV SEMESTER
PY 404 PHARMACEUTICAL CHEMISTRY-V (BIOCHEMISTRY) Theory

Biochemical organization of the cell and transport processes across cell membrane.
The concept of free energy, determination of charges in free energy system from equilibrium constant and reduction potential, bioenergetics, production of ATP and its biological significance.

Structure and Functions of Proteins: Amino acids and Peptides, Determination of Primary structure and higher orders of structure.

Enzymes: Nomenclature, Kinetics ans its Mechanism of action, Mechanism of Inhibition,Isoenzymes, enzymes in technical diagnosis.

Co-enzymes: Metals as coenzymes and their significance and Vitamins as coenzymes and their
significance.

Carbohydrate Metabolism: Conversion of Polysaccharide to Glucose 1-Phosphate, Glycolysis and Fermentation and their regulation, Gluconeogenesis and Glycogenolysis, metabolism of galactose and galactosemia, role of sugar nucleotide in biosynthesis, pentosephosphate pathway.

The Citric acid cycle:
The significance, reaction and energetics of cycle, amphibolic role of cycle, Glyoxalic Acid Cycle.

Lipid Metabolism:
Oxidation of fatty acids, Beta Oxidation and energetic, alpha oxidation,omega oxidation, Biosynthesis of Ketone bodies and their utilisation, Biosynthesis of saturated and unsaturated fatty acids and eicosanoids, phospholipids, sphingolipids.

Biological oxidation: Redox Potential, enzymes and co-enzymes involved in oxidation reduction and its control. The respiratory chain, its role in energy capture and its control, energetic of oxidative phosphorylation, inhibitors of respiratory chain and oxidative phosphyrlation, mechanism of oxidative phosphorylation.

Nitrogen & Sulphur Cycle: Nitrogen fixation, ammonia assimilation, sulphur activation, sulphate reduction, incorporation of sulphur in organic compounds, release of sulphur from organic compounds

Metabolism of Ammonia and Nitrogen Containing monomers: Nitrogen balance, biosynthesis of amino acids, catabolism of amino acids, conversion of amino acids to specialized products, assimilation of ammonia , urea cycle, metabolic disorders of urea cycle, metabolism biosynthesis, formation of bile pigment, hyperbilirubinemia, purine biosynthesis, purine nucleotide interconversion, pyrimidine biosynthesis, and formation of deoxyribonucleotides.

Disorders of Carbohydrate, Lipid and Protein Metabolism: Biomedical Importance and Implications in Clinical Biochemistry. Diagnostic tests for detection of metabolic disorders.

Biosynthesis of nucleic Acids: Brief introduction to genetic organisation, organisation of mammalian genome, alteration and rearrangement of genetic material, biosynthesis of DNA and its replication, mutation, physical and chemical mutagenesis/ carcinogenesis, DNA repair mechanism, biosynthesis of RNA.

Genetic code and Protein synthesis: Genetic code, Components of protein synthesis and inhibition of protein synthesis. Brief account of genetic engineering and polymerase chain reactions. Regulation of gene expression.

List of Practicals !!! BOOKS RECOMMENDED

RGPV / RGTU B Pharma, PHARMACY 4th (IV) Semester PY 402 Pharmaceutics –V (Dosage Form Design) syllabus (Theory)

Tags: RGPV, B Pharma, PHARMACY syllabus, PY 402 Pharmaceutics –V (Dosage Form Design) syllabus (THEORY), B. Pharmacy, IV Semester syllabus, BPharma 4th Semester syllabus, RGPV PY 402 syllabus

Rajiv Gandhi Technological University, Bhopal (MP)
BPharma BRANCH: PHARMACY FOURTH IV SEMESTER
PY 402 Pharmaceutics –V (Dosage Form Design) (THEORY)

Pharmaceutical preformulation: - Definition and scope, Establishment and importance of following physicochemical parameters Solubility, pKa and selection of suitable salt, partition coefficient, dissolution, polymorphism, microscopy and powder properties, stability and drug-excipient compatibility Pharmaceutical factors influencing drug formulation.

Study of different types of formulation additives: Diluents, Binders, Disintegrating agents, Lubricants, Solvents, Co-solvents and Vehicles, Preservatives, Suspending agents, Emulsifying agents, Antioxidants, Preservatives, colouring, flavoring and sweetning agents, Viscosity enhancers, ointment and suppositories bases

Polymers and biodegradable polymers: Classification, Methods of synthesis, Properties, Characterization and evaluation. Brief introduction of biodegradable polymers, pharmaceutical applications of polymers.

Dissolution stability and degradation study: Chemical stability, pathways of degradation, physical and phase transformation, stability testing protocols for various pharmaceutical dosage forms, determination of expiry date (shelf life) and overage calculations, stabilization of pharmaceutical formulations.

Drug product design: Stages of drug discovery and development process, Importance of product design, considerations.

Dissolution technology: Theories of dissolution, factors affecting dissolution, design of various dissolution apparatus, dissolution media, dissolution testing of different types of dosage formulations, data interpretation, mathematical models for predication of dissolution of profile.

List of Practicals !!! BOOKS RECOMMENDED

RGPV / RGTU B Pharma, PHARMACY 4th (IV) Semester PY 402 Pharmaceutics –V (Dosage Form Design) syllabus (Practicals)

Tags: RGPV, B Pharma, PHARMACY syllabus, PY 402 Pharmaceutics –V (Dosage Form Design) syllabus (Practicals), B. Pharmacy, IV Semester syllabus, BPharma 4th Semester syllabus, RGPV PY 402 syllabus

Rajiv Gandhi Technological University, Bhopal (MP)
BPharma BRANCH: PHARMACY FOURTH IV SEMESTER
PY 402 Pharmaceutics –V (Dosage Form Design) (Practicals)

Related: PY 402 Pharmaceutics –V (Dosage Form Design) (THEORY)

List of practicals: (Any ten)

1. Establish the following preformulation parameters of the given drug sample.
(a) Melting point (b) solubility (c) intrinsic solubility (d) pKa (e) Partition coefficient
2. Establish the following preformulation parameters of the given drug sample.
(a) Particle size distribution (b) Flow proportion (c) Bulk deurity (d) Carr’s index (e) Compression preparation.
3. Study the drug excipient compatibility of given drug with commonly used excipent by TLC technique.
4. Estimate the self life of the given drug
5. Study the effect of mesture content on chemical stability of aspirin.
6. Study the effect of temperation on stability of given photosensitive drug.
7. Determine the molecular Mass of given polymer by viscometer.
8. Perform the in-vitro dissolution study of given the sample of tablet.
9. Study the effect of presence of surfactant in dissolution of tablet cantoning poorly soluble drug.
10. Study the effect of solvent / co-solvent hydrotropic agents on solubility of given drug.
11. Study the effect of pH of dissolution on in-vitro dissuasion study.
12. Compare the dissolution profile of two marketed tablet products.

References:
1. Swarbrick J., Boylan J.C., Encydopedia of Pharmaceutical Technology, Second edition, Volume-1,2,3, Marcel Dekker, Inc. Newyork.
2. Qice yihong, ChenY, Zhang G.G.Z., Developing solid Oral dosage forms- Pharmaceutical Theory and Practice charon Tech Ltd.
3. Allen L.V., Popovich N.G., Ansel H.C., Ansel’s Pharmaceutics design and drug delivery systems, Eight edition, B.I. Publication Pvt. Ltd.
4. Aulton M.E. Pharmaceutics- The science of dosage form design” second edition., Churchill Livingstone Pvt. Ltd.
5. Banker G.S., Rhodes C.T., Modern Pharmaceutics” second edition, Marcel Dekker, Inc., Newyork.
6. Kanig J.J., Liebermen H.A., Lachman L. “The theory and Practics of Industrial Pharmacy, Varghese Publishing House, Bombay.
7. Rowe RC, Sheskey P.J., Owen S.C., Handbook of Pharmaceutical Excipents, Fifth edition, Pharmaceutical Pr.
8. Bugay D.E., Findlay W.P., Pharmaceutical Excipents, Marcel Dekker, Inc. Newyork.
9. Kim C.J., Advanced Pharmaceutics- Physiochemical Principle CRC Press, Florida.
10. Jan N.K., Pharmaceutical Product Development, CBS Publishers and distributors, New Delhi.
11. Shah D.H., “SOP Guidelines”, Business Horizons Publishers, New Delhi.
12. Wachter A.H., Nash R.A., “Pharmaceutical Process validation, Marcel Dekker, Inc. Newyork.
13. Mazzo D.J., “International stability Testing” Interpha Press, Inc. Illinois.
14. Gibaldi M., Perriner D., “Pharmacokinetics:, Marcel Dekker Newyork.