RGPV / RGTU B Pharma, PHARMACY 4th (IV) Semester PY 402 Pharmaceutics –V (Dosage Form Design) syllabus (Theory)

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Rajiv Gandhi Technological University, Bhopal (MP)
BPharma BRANCH: PHARMACY FOURTH IV SEMESTER
PY 402 Pharmaceutics –V (Dosage Form Design) (THEORY)

Pharmaceutical preformulation: - Definition and scope, Establishment and importance of following physicochemical parameters Solubility, pKa and selection of suitable salt, partition coefficient, dissolution, polymorphism, microscopy and powder properties, stability and drug-excipient compatibility Pharmaceutical factors influencing drug formulation.

Study of different types of formulation additives: Diluents, Binders, Disintegrating agents, Lubricants, Solvents, Co-solvents and Vehicles, Preservatives, Suspending agents, Emulsifying agents, Antioxidants, Preservatives, colouring, flavoring and sweetning agents, Viscosity enhancers, ointment and suppositories bases

Polymers and biodegradable polymers: Classification, Methods of synthesis, Properties, Characterization and evaluation. Brief introduction of biodegradable polymers, pharmaceutical applications of polymers.

Dissolution stability and degradation study: Chemical stability, pathways of degradation, physical and phase transformation, stability testing protocols for various pharmaceutical dosage forms, determination of expiry date (shelf life) and overage calculations, stabilization of pharmaceutical formulations.

Drug product design: Stages of drug discovery and development process, Importance of product design, considerations.

Dissolution technology: Theories of dissolution, factors affecting dissolution, design of various dissolution apparatus, dissolution media, dissolution testing of different types of dosage formulations, data interpretation, mathematical models for predication of dissolution of profile.

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