RGPV / RGTU B Pharma, PHARMACY 4th (IV) Semester PY 404 PHARMACEUTICAL CHEMISTRY-V (BIOCHEMISTRY) syllabus Theory
BRANCH: BPharma, PHARMACY FOURTH IV SEMESTER
PY 404 PHARMACEUTICAL CHEMISTRY-V (BIOCHEMISTRY) Theory
The concept of free energy, determination of charges in free energy system from equilibrium constant and reduction potential, bioenergetics, production of ATP and its biological significance.
Structure and Functions of Proteins: Amino acids and Peptides, Determination of Primary structure and higher orders of structure.
Enzymes: Nomenclature, Kinetics ans its Mechanism of action, Mechanism of Inhibition,Isoenzymes, enzymes in technical diagnosis.
Co-enzymes: Metals as coenzymes and their significance and Vitamins as coenzymes and their
Carbohydrate Metabolism: Conversion of Polysaccharide to Glucose 1-Phosphate, Glycolysis and Fermentation and their regulation, Gluconeogenesis and Glycogenolysis, metabolism of galactose and galactosemia, role of sugar nucleotide in biosynthesis, pentosephosphate pathway.
The Citric acid cycle:
The significance, reaction and energetics of cycle, amphibolic role of cycle, Glyoxalic Acid Cycle.
Oxidation of fatty acids, Beta Oxidation and energetic, alpha oxidation,omega oxidation, Biosynthesis of Ketone bodies and their utilisation, Biosynthesis of saturated and unsaturated fatty acids and eicosanoids, phospholipids, sphingolipids.
Biological oxidation: Redox Potential, enzymes and co-enzymes involved in oxidation reduction and its control. The respiratory chain, its role in energy capture and its control, energetic of oxidative phosphorylation, inhibitors of respiratory chain and oxidative phosphyrlation, mechanism of oxidative phosphorylation.
Nitrogen & Sulphur Cycle: Nitrogen fixation, ammonia assimilation, sulphur activation, sulphate reduction, incorporation of sulphur in organic compounds, release of sulphur from organic compounds
Metabolism of Ammonia and Nitrogen Containing monomers: Nitrogen balance, biosynthesis of amino acids, catabolism of amino acids, conversion of amino acids to specialized products, assimilation of ammonia , urea cycle, metabolic disorders of urea cycle, metabolism biosynthesis, formation of bile pigment, hyperbilirubinemia, purine biosynthesis, purine nucleotide interconversion, pyrimidine biosynthesis, and formation of deoxyribonucleotides.
Disorders of Carbohydrate, Lipid and Protein Metabolism: Biomedical Importance and Implications in Clinical Biochemistry. Diagnostic tests for detection of metabolic disorders.
Biosynthesis of nucleic Acids: Brief introduction to genetic organisation, organisation of mammalian genome, alteration and rearrangement of genetic material, biosynthesis of DNA and its replication, mutation, physical and chemical mutagenesis/ carcinogenesis, DNA repair mechanism, biosynthesis of RNA.
Genetic code and Protein synthesis: Genetic code, Components of protein synthesis and inhibition of protein synthesis. Brief account of genetic engineering and polymerase chain reactions. Regulation of gene expression.