PROGRAMME: B.E. Computer Science and Engineering, VIII Semester
Course: CS-8301 BIOINFORMATICS
Introduction to bioinformatics, objectives of bioinformatics, Basic chemistry of nucleic acids, structure of DNA & RNA, Genes, structure of bacterial chromosome, cloning methodology, Data maintenance and Integrity Tasks.
Unit-II Bioinformatics Databases & Image Processing
Types of databases, Nucleotide sequence databases, Protein sequence databases, Protein structure databases, Normalization, Data cleaning and transformation, Protein folding, protein function, protein-purification and characterization, Introduction to Java clients, CORBA, Using MYSQL, Feature Extraction.
Unit-III Sequence Alignment and database searching
Introduction to sequence analysis, Models for sequence analysis, Methods of optimal alignment, Tools for sequence alignment, Dynamics Programming, Heuristic Methods, Multiple sequence Alignment
Unit-IV Gene Finding and Expression
Cracking the Genome, Biological decoder ring, finding genes through mathematics & learning, Genes prediction tools, Gene Mapping, Application of Mapping, Modes of Gene Expression data, Mining the Gene Expression Data
Unit-V Proteomics & Problem solving in Bioinformatics
Proteome analysis, tools for proteome analysis, Genetic networks, Network properties and analysis, complete pathway simulation: E-cell, Genomic analysis for DNA & Protein sequences , Strategies and
options for similarity search , flowcharts for protein structure prediction .
CS 8301 BIOINFORMATICS List of References
1.Gopal & Jones, BIOINFORMATICS with fundamentals of Genomics & Proteomics ,TMH Pub
2.Rastogi , Bioinformatics –Concepts , skills & Applications , CBS Pub
3.Bergeron , Bioinformatics computing , PHI
4.Claverie , Bioinformatics , Wiley pub
5.Baxevanis , Bioinformatics , Wiley Pub
6.Stekel , Micrarray BioInformatics , Cambridge