BPharma, 5th (V) Semester RGPV / RGTU PY-503 PHARMACEUTICAL CHEMISTRY -VI (MEDICINAL CHEMISTRY- I) Syllabus B Pharma, PHARMACY 5th (V) Semester Syllabus

RGTU/RGPV PY-503 PHARMACEUTICAL CHEMISTRY -VI Syllabus
BPharma 5th sem (MEDICINAL CHEMISTRY- I) Syllabus
BPharma 5th - Fifth Semester Syllabus


B. PHARMA- V SEMESTER (Modified on 14/06/10) Effective for 2008 – 2009 Batch

PY-503 PHARMACEUTICAL CHEMISTRY -VI (MEDICINAL CHEMISTRY- I) Course Contents:

Introduction to medicinal chemistry
  • Principles of drug discovery: Basic principles of medicinal chemistry, physicochemical and steric aspects (optical, geometric and bioisosterism) of drug molecules and biological actions.
  • Receptors and drug action: Receptor theories, affinity, receptor and biologic response.
  • Drug metabolism: Phase I (biotransformation reactions), phase II (conjugation reactions), factor affecting drug metabolism.
  • Prodrugs and drug latentiation: Basic concepts, prodrug of functional groups, bioprecursor  prodrugs, chemical delivery system.
Classification and mode of action, uses, structure activity relationship including  physicochemical, steric aspects and resents advances in research of the following categories of drugs:

Drugs affecting neurotransmission
  • Drugs affecting cholinergic neurotransmission: Neurochemistry and stereochemistry of  acetylcholine, acetylcholine mimetics-muscarinic agonists, acetlycholinesterase inhibitors, acetylcholine antagonists-muscarinic anatagonists, nicotinc antagonists-neuromuscular blocking agents, ganglionic blocking agents.
  • Drugs affecting adrenergic neurotransmission: Neurochemistry and stereochemistry of norepinephrine, sympathomimetic agents, sympatholytic agents, drugs affecting catecholamine biosynthesis, drugs affecting catecholamine storage and release, ergot alkaloids, xanthine bronchodilators
  • Drugs affecting serotonergic neurotransmission: Neurochemistry and stereochemistry of serotonin, 5-HT agonists, 5-HT antagonists.
  • Local anesthetics: Molecular mechanism of action, chemical aspects.
Drugs affecting immune systems
  • Non-steroidal anti-inflammatory agents: Chemistry of chemical mediators of inflammation (prostaglandins, thromboxanes, prostacyclin and leukotrienes), antipyretic analgesics.
  • Antihistaminics and related antiallergics: Neurochemistry and stereochemistry of histamine,
LIST OF PRACTICALS:
(Minimum fifteen experiments should be performed in the semester. Student should aware with safety parameters and handling of chemicals related to following experiments)
1. Synthesis and characteriazation of Tropenone from Maleyde aldehyde.
2. Synthesis and characteriazation of Scopolamine from Tropenol.
3. Synthesis and characterization of chlorzoxazone from 2-amino-4-chlorphenol.
4. Synthesis and characterization of Clemastine.
5. Synthesis and characterization of Tripelennamine.
6. Synthesis and characterization of Oxyphenbutazone.
7. Synthesis and characterization of trihexyl phenylidine.
8. Synthesis and characterization of Aspirin from salicylic acid.
9. Synthesis and characterization of Benzimadazole from benzyl chloride.
10. Synthesis and characterization of Sulphonilamide from Aniline.
11. Synthesis and characterization of Paracetamol from Para amino phenol.
12. Synthesis and characterization of Ibuprofen from isobutyl benzene.
13. Synthesis and characterization of Antipyrine
14. Synthesis and characterization of Phenyl benzoate.
15. Synthesis and characterization of Benzenilide.
16. Synthesis and characterization of Phenindione.
17. Synthesis and characterization of Methyl pyrazolone.

BOOKS RECOMMENDED:
1. Foye, W.C., Principles of Medicinal Chemistry, Lea and Febiger, Philadelphia.
2. Wolff , M.E. Ed., Burger’s Medicinal Chemistry, John Wiley and Sons, New York.
3. Hansch, C., Comprehensive Medicinal Chemistry, Pergarnon Press, Oxford.
4. Delagado, J.N. and Remers, W.A.R, Wilson and Giswold’s Text Book of Organic,Medicinal and Pharmaceutical Chemistry, J.Lippincott Co., Philadelphia.
5. Nogrady, T., Medicinal Chemistry-A Biochemical Approach, Oxford University Press, New York, Oxford.
6. Kar, A., Medicinal Chemistry, Willey Eastern Ltd., New Delhi.
7. Patrick, G., An Introduction to Medicinal Chemistry, Scientific Distributors, Mumbai.
8. Malone, Dyson and Purey, May’s Chemistry of Synthetic Drugs.
9. Parimoo, P., Text Book of Medicinal Chemistry, CBS Publishers and Distributors, New Delhi.
10. Thomas, G., Introduction to Medicinal Chemistry, CBS Publishers and Distributors, New Delhi.

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