BPharma, PY 104 Pharmaceutical Chemistry - I (Physical Chemistry) 1st First Semester RGPV / RGTU B Pharma, PHARMACY 1st First Semester Syllabus

BPharma, PY 104 Pharmaceutical Chemistry - I (Physical Chemistry) 1st First Semester RGPV / RGTU B Pharma, PHARMACY 1st First Semester Syllabus

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RGTU/RGPV PY 104 Pharmaceutical Chemistry - I (Physical Chemistry) Syllabus
BPharma 1st sem PY 104 Pharmaceutical Chemistry - I (Physical Chemistry) Syllabus
B. PHARMA-1st - First SEMESTER Syllabus (Modified on 27/01/11)
 
PY 104 Pharmaceutical Chemistry - I (Physical Chemistry) Course Contents:



1. Atomic, Molecular Structure and Chemical Bonding
 
Atomic Structure
Origin of the elements, valency, the mole concept, molar mass, compounds, chemical formulae. Introduction to atomic structure. Electronic configuration of atoms and relationship to structure of the Periodic Table. Properties of atoms, size, ionization potential, electronegativities etc. Quantum numbers, orbitals and the Aufbau process. Rydberg formula, Bohr atom, dual wave/particle nature of light and electrons. Angular and radial wavefunctions of atomic orbitals. H atom spectrum.

Molecular structure and chemical bonding:
LCAO approximation, molecular orbital theory and molecular orbital energy level diagrams. Polarisation and polarisibility of molecules. Molecular orbital electronic configuration of homonuclear diatomic molecules. Hydrogen bonding. Valence bond theory- important features, concept of hybridization involving s, p, d and f orbitals, shapes of molecules, VSEPR theory. Electron spin. Polyelectronic atoms and the orbital approximation. Quantum Mechanics

Postulates of quantum mechanics: Eigenvalues and expectation values. Time independent Schrodinger equation. The Born interpretation of the wavefunction. Solutions for particles in boxes. Schrodinger equation applied to vibrational and rotational motion. Interelectronic repulsion: SCF methodology and Hartree-Fock wavefunctions. Slater type orbitals. Spin-orbit coupling. Atomic states and Hund's rules.

2. Physico-chemical properties of substances
Polarity of substances, dipole moment, dielectric constant, refractive index, optical rotation, density, specific gravity, viscosity, molar refraction, parachor relative permitivity, Bonding and non-bonding interactions, roentgen diffraction, polymorphism,isomorphism, isotropy, anisotropy, liquid crystals.

3. Thermodynamics
Fundamentals of thermodynamics: System and surroundings, extensive and intensive properties, state functions, types of processes. spontaneity of chemical change; Free Energy. Equilibrium; Enthalpy and Entropy and spontaneous change
First law of thermodynamics: Concept of work, heat internal energy and enthalpy, standard state, thermochemistry, thermochemical laws, heat capacity, molar heat capacity, Hess's law of constant heat summation; Enthalpies of bond dissociation, combustion, formation, atomization, sublimation, phase transition, hydration, ioniz-ati on and solution.
Second law of thermodynamics: Spontaneity of processes; ΔS of the universe and ΔG of the system as criteria for spontaneity, ΔGo (Standard Gibbs energy change) and equilibrium constant.
Third Law of Thermodynamics: calculation of absolute entropies; specific heat; variation in enthalpy with temperature. Helmholtz and Gibbs energies, chemical potential, conception of absolute entropy. Calculations involving entropy and enthalpy; dealing with ions etc. Variation of G and K with temperature: Ellingham Diagrams, Giauque Function.

4. Chemical equilibrium 
  • Law of chemical equilibrium, Equilibrium constant, equilibrium degree of conversion and its  control by reaction, conditions, LeChatelier principle, standard change of Gibbs energy during reaction, Equilibrium constants and their significance, Factors affecting equilibrium concentration, pressure, temperature , effect of catalyst.
  • Acid-base catalysis, decomposition of medicinal compounds, accelerated stability analysis, kinetics of enzyme catalysed reactions.
Integrated rate equations for simple reaction types. Use of integrated rate equations to determine order. Fractional lives. Molecularity vs. order
Kinetics of more complex reactions: approach to equilibrium, parallel and consecutive reactions. Rate determining step. Steady state approximation and its uses.
Effect of temperature on rate and rate constant. Arrhenius equation, significance of activation energy. Kinetics of reactions in the gas phase - simple collision theory. Reactions in solution - transition state theory. Enthalpy and entropy of activation. Effects of solvent polarity and viscosity on rates of reaction.
Further applications of the steady state approximation - radical chain reactions. General definitions. Stoichiometry vs mechanism. Dependence of rate on concentration: rate constant and order of reaction. Experimental determination of rates of reaction. Determination of orders from rate measurements.

5. Phase equilibrium
Gibbs phase rule, types of systems, one component equilibrium, Clapeyron and Clausius-Clapeyron equations, two component systems, Henry´s law, sparingly miscible liquids, solubility of solid substances, system solid substance - solvent, melts, Raoult´s law and its application, cryoscopy and ebullioscopy, osmotic pressure, three component systems, Nernst distribution law, extraction, ternary diagram, system of three liquids, interfacial phenomena, adsorption on solid surfaces. Phase diagram of mixture fractional distillation, eutectic mixtures.

6. Surface Chemistry
Adsorption : Physisorption and chemisorption and their characteristics, factors affecting adsorption of gases on solids - -Freundlich and Langmuir adsorption isotherms, adsorption from solutions.
Catalysis : Homogeneous and heterogeneous, activity and selectivity of solid catalysts, enzyme catalysis and its mechanism. acid base catalysis, theories of catalysis, catalytic poisoning and Pharmaceutical application of catalysis. 
 
7. States of Matter
 
Gaseous State: Measurable properties of gases; Gas laws - Boyle's law, Charle's law, Graham's law of diffusion, Avogadro's law, Dalton's law of partial pressure; Concept of Absolute scale of temperature; Ideal gas equation, Kinetic theory of gases; Concept of average, root mean square and most probable velocities; Real gases, deviation from Ideal behaviour, compressibility factor, van der Waals equation, liquefaction of gases, critical constants.
Liquid State: Solutions, Lowering of vapour pressure and Raoult's Law, osmosis  and osmotic pressure, measurement of osmotic pressure, isotonic solutions, pharmaceutical applications of osmosis, theories of semipermeable membranes, colligative properties, elevation of boiling point and its experimental determination, depression of freezing point and its determination, distribution law and solvent extraction method, electrolyte and non electrolytes, Debye-Huckel theory, ionic equilibria in blood, characterization of acid base functional groups.
Solid State: Classification of solids: molecular, ionic, covalent and metallic solids, amorphous and crystalline solids (elementary idea); Bragg's Law and its applications, Unit cell and lattices, packing in solids (fcc, bcc and hcp lattices), voids, calculations involving unit cell parameters, imperfection in solids; electrical, magnetic and dielectric properties.

List of Practicals
1. Determination of specific gravity of liquids using pycnometer and density bottle.
2. To study the effect of salt/Sugar in different concentration on density of water.
3. To study the effect of temperature on density of given liquid .
4. Determination of the viscosity of a liquid by Ostwald viscometer.
5. To study the effect of concentration on viscosity.
6. To study the effect of temperature on viscosity
7. Determination of the percent composition of a mixture of ethanol and water by viscometric method.
8. Determination of the surface tension of a pure liquid by the capillary rise method.
9. To determine the surface tension of liquid using stalagmometer.
10. To study the effect of temperature on surface tension.
11. To study the effect of surfactant on surface tension.
12. Determination of the percentage composition of mixture of ethanol and water by surface tension method.
13. Determination of interfacial tension between benzene and water by the drop size method.
14. Determination of the parachor value of an organic liquid.
15. Determination of solubility of benzoic acid over a range of temperatures and calculation of its heat of solution.
16. Determination of the mutual solubility curve of phenol and water.
17. Preparation of buffer solutions and measurement of pH.
18. Distillation of a mixture.
19. Determination of phase diagram in ternary system containing a single pair of sparingly miscible liquids.
20. Determination of distribution coefficient of substance between two immiscible liquids . (succinic acid between ether and distilled water).

Recommended Reading:
1. P W Atkins, the Elements of Physical Chemistry, 2nd Ed., OUP, 1996
2. P W Atkins, Physical Chemistry 7th Ed., OUP, 2002
3. B G Cox, Modern Liquid Phase Kinetics, Oxford Science Publications, 1994.
4. J.R. Barrante: Physical Chemistry of Life Sciences, Printeil.
5. K.J. Laidler: Physical Chemistry with Biological Applications, Benjamin.
6. S.C. Wallwork: Physical Chemistry for Students of Pharmacy and Biology, Longman.
7. L. M. Atherden: Bentley and Driver’s-Textbook of Pharmaceutical Chemistry, Oxford University Press, Delhi.
8. A.J. Mce: Physical Chemistry, E.L. B.S., London.
9. H.H.Willard, L.L. Merritt and J.A. Dean: Instrumental Methods of Analysis, Van Nostrand Reinhold, New York.
10. Samuel Glasstone and David Lewis: Elements of Physical Chemistry, Macmiilan Press, London.
11. A.H. Beckett and J.B. Staenlake: Practical Pharmaceutical Chemistry, Vol. I and II. The Athlone Press of the University of London.
12. Gross J.M. and Wiseall B. Principle of Physical Chemistry, Macdonald and Evans Plymouth, England.
13. Gareth Morris J. A Biologists Physical Chemistry, Edward Arnold, London.
14. Martin A.N. Physical Pharmacy, Lea and Febiger, Philadelphia.
15. Chang R. Physical Chemistry with Application to Biological System. Collier Macmilliar Publisher, London.
16. Barrow G.M. Physical Chemistry. McGraw-Hill, London.
17. Yadav J.B. Advanced Practical Physical Chemistry, Geol Publisher House, Meenet, India.
18. Vogel’s Text Book of Quantitative Inorganic Analysis including Elementary Instrumental Analysis, Longman, London.
BPharma, PY 103 PHARMACEUTICS –I (Introduction to pharmaceutics) 1st First Semester RGPV / RGTU B Pharma, PHARMACY 1st First Semester Syllabus

BPharma, PY 103 PHARMACEUTICS –I (Introduction to pharmaceutics) 1st First Semester RGPV / RGTU B Pharma, PHARMACY 1st First Semester Syllabus

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RGTU/RGPV PY 103 PHARMACEUTICS –I Syllabus
BPharma 1st sem PHARMACEUTICS –I Syllabus
B. PHARMA-1st - First SEMESTER Syllabus (Modified on 27/01/11)
 
PY 103 PHARMACEUTICS –I (Introduction to pharmaceutics) Course Contents:

1. History of pharmaceutical practice through ages. Various system of medicines. Significance of pharmacopoeias with special reference to Indian, British, United States, International and Extra pharmacopoeias.
2. Routes of administration and classification of pharmaceutical dosage form.
3. Definition, general formulation, principles and procedures adopted for dispensing and official products of the following-
Aromatic waters, Solutions, Syrups ,Mixtures, Spirits, Elixers, Linctuses, lotions, liniments, Mixtures, Glycerites, Gargles, Mouth washes, Inhalations powders, Capsules, Tablet triturates, Ointments, Creams, pastes, Suppositories and ophthalmics, Emulsions, Suspension, Milk and Magmas, Mucilages, Jellies, Infusion, Decoctions, Tinctures and Extracts.
4. Pharmaceutical Calculation: Different systems of weights and measures, Dilution and conc. of solutions, Percentage solution, Calculation by allegation, Proof Spirits, Calculation of doses, Displacement value.
5. Detailed methods employed in the preparation of plant extractives.

LIST OF PRCTICALS
1. Study Indian Pharmacopoeia, British Pharmacopoeia, United States Pharmacopoeia and Extra Pharmacopoeia.
2. Prepare and submit Camphor Water I.P.
3. Prepare and submit Chloroform Water I.P.
4. Prepare and submit Conc. Dill Water I.P.
5. Prepare and submit Aqueous Iodine Solution I.P.
6. Prepare and submit Weak Iodine Solution I.P.
7. Prepare and submit Strong Iodine Solution I.P.
8. Prepare and submit Cresol with Soap Solution I.P.
9. Prepare and submit chloroxylenol Solution I.P.
10. Prepare and submit Simple Syrup I.P.
11. Prepare and submit Simple syrup U.S.P.
12. Prepare and submit Chloroform Spirit I.P.
13. Prepare and submit Simple elixir I.P.
14. Prepare and submit Calamine Lotion I.P.
15. Prepare and submit Calamine Lotion USP, oily.
16. Prepare and submit Turpentine Liniment I.P.
17. Prepare and submit Liquid Paraffin Emulsion I.P
18. Prepare and submit Tragacanth Mucilage I.P.
19. Prepare and submit Milk of Magnesia I.P
20. Prepare and submit Bentonite Magma U.S.P.
21. Prepare and submit Borax Glycerin I.P.
22. Prepare and submit Tannic acid Glycerin I.P.
23. Prepare and submit Mandle’s Paint. B.P.
24. Prepare and submit Simple Linctuses I.P.
25. Prepare and submit Menthol and Eucalyptus Inhalation B.P.C
26. Prepare and submit orange / lemon Tincture I.P.
27. Prepare and submit compound benzoin Tincture I.P.
28. To prepare & submit codeine linctuses NFI , BNF.
29. To prepare & submit zinc sulphate & zinc chloride mouthwash IP.
30. To prepare & submit Potassium permanganate gargle NFI 1979.
31. To prepare & submit salicylic acid lotion BPC.
32. To prepare magnesium trisilicate mixture BPC.
33. To prepare & submit Chalk mixture pediatric BPC.
34. To prepare & submit magnesium hydroxide mixture BP.
35. To prepare & submit castor oil emulsion NFI .
36. To prepare & submit liquid paraffin & magnesium hydroxide emulsion BPC.
37. To prepare & submit lubricating gel.
38. To prepare & submit Peppermint water IP.
39. To prepare & submit sodium chloride solution IP.
40. To prepare & submit sodium chloride mouthwash .
41. To prepare & submit oral rehydration salt BP.
42. To prepare & submit soap liniment.
43. To prepare & submit sodium alginate jelly.
44. To prepare & submit lubricating jelly with cellulose ether base.
45. To prepare & submit compound syrup of ferrous phosphate IP 55 (Parrishs Food) by chemical interaction.

Books Recommended
1. Indian Pharmacopoeia.
2. British Pharmacopoeia.
3. United State Pharmacopoeia.
4. Lachmen, L. & Lieberman, H.A., “Theory and Practice of Industrial Pharmacy”, Verghese publishing house, Bombay.
5. Gennaro, A.R., Remington’s “The Science and practice of Pharmacy”, Lippincot, Wiliams & Wilkins, Philadelphia.
6. Aulton, M.E., “Pharmaceutics- The science of doses form design”, Churchill Livingstone, London.
7. Banker and Rhodes, Modern Pharmaceutics. Marcel Dekker Inc. NY.
8. Kibbe, “ Hand book of Pharmaceutical Excipients., Pharmaceutical Press, London.
9. Martin, Physical Pharmacy.
10. N. K. Jain, Text Book of Professional Pharmacy, CBS Publishers & Distributors. New Delhi.
11. N.K. Jain, Pharmaceutical product development, CBS Publishers & Distributors. New Delhi.
12. B. M. Mithal, Text Book of Pharmaceutical Formulation.
13. Pharmaceutical Dosage Forms & Drug Delivery System. Loyd.V.Allen, Jr.Nicholas, G.Popovich, Howad C.Ansel
14. Textbook of Pharmaceutics, Bentley, E.A. Rawlins
BPharma, PY102 COMPUTER APPLICATIONS 1st First Semester RGPV / RGTU B Pharma, PHARMACY 1st First Semester Syllabus

BPharma, PY102 COMPUTER APPLICATIONS 1st First Semester RGPV / RGTU B Pharma, PHARMACY 1st First Semester Syllabus

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RGTU/RGPV PY102 COMPUTER APPLICATIONS Syllabus
BPharma 1st sem COMPUTER APPLICATIONS Syllabus
B. PHARMA-1st - First SEMESTER Syllabus (Modified on 27/01/11)
 
PY102 COMPUTER APPLICATIONS Course Contents:

Interlocution to Computer- Its Types and uses, Computer Generations, Hardware, software, Elements of computer system, Number Systems:- Decimal, Binary, Octal, hexadecimal, Storage Devices- primary memory, Secondary Memory, Input and output  devices.

Operating system- Basic Concepts, Organization, functions, operations and types, Features of DOS, Windows and Unix operating systems. Dos Commands.

Data Transmission and Networks- Basic Concepts LAN, MAN, WAN. Network Topologies, TCP/IP, Worldwide web, URL, HTML. Transmission Media.

Programming – High Level languages, Machine languages, Syntax, semantics. Compiler, Interpreter Algorithms and Flowchart.

Programming Language ‘C’ – Data types, Constants, variables, Operators, symbolic constants, input and output, increment and decrement operators. Control Structures: while, do- while, for, if, if-else, and switch statement. Functions, header files, recursion, pointers and arrays, structures.

Application software- Word processing, formatting, printing setups, mail merge, Table Handling, picture handling, spreadsheet programs, workbooks/ worksheets, formatting of sheets, formulae and functions, graphs, Import and export of files / data. Presentation Packages, Slide designing.

Practicals:
Introduction to various components of computer, Use of External & Internal DOS Commands, MS- Office – MS Word, MS, Excel, Powerpoint. A simple documentation preparation & printing. Usage of printer & other components. Simple programs in C.

Book Recommended:
1. V. Rajaraman: Fundamentals of computer, Iind Edition, East Economy Edition.
2. E. Balaguruseamy: Programming In C, TMH Pub
3. D.S. Yadav: Fundamentals of Information Technology, New Age Publication.
4. P.K. Sinha: Fundamentals of Computer
5. Computer Architecture (Schaum’s outline) CARTER, TMH
BPharma, PY 101(B) Remedial Biology 1st First Semester RGPV / RGTU B Pharma, PHARMACY 1st First Semester Syllabus

BPharma, PY 101(B) Remedial Biology 1st First Semester RGPV / RGTU B Pharma, PHARMACY 1st First Semester Syllabus

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RGTU/RGPV PY 101(B) Remedial Biology Syllabus
BPharma 1st sem Remedial Biology Syllabus
B. PHARMA-1st - First SEMESTER Syllabus (Modified on 27/01/11)
 
PY 101(B) Remedial Biology Course Contents:


1. Plant Anatomy and Physiology :
i. Morphology and Anatomy of flowering plant and its parts like root, stem, bark, wood, leaf, flower, fruit and seed. Modification of root and stem.
ii. Transportation, photosynthesis and respiration in plants, Plant growth and development.
iii. Structure of plant cell, Different types of plant tissues and their functions.
 
2. Structure and functions :
i. Cell- the unit of life.
ii. Biomolecules – Lipids, polysaccharides, Proteins, and nucleic acids. Enzymes and cofactors , their classification , chemistry, mechanism of action and factors affecting enzyme activity.
iii. Cell cycle and cell division, stages of mitosis and meiosis, and their significance.
 
3. Living systems
i. Biological classification – Five kigdoms Monera, Prostita, Fungi, plantae and animalia. Viruses, viroids and lichens.
ii. Animal kingdom - Classification and its basis
iii. Plant kingdom – Algae, bryophytes, Pteridophytes, Gymnosperms, Angiosperms. Plant life cycles and alteration of generations.

4. Genetics and Evolution :
i. Principles of inheritance and variation – Mendals laws, inheritance of one gene and two gene, sex determination, mutation and genetic disorders.
ii. Molecular basis of inheritance – DNA, RNA, Replication, Transcription, Genetic code, Translation, regulation of gene expression, DNA fingerprinting, Human Genome Project.
iii. Evolution – Origin of life, theory of evolution of life forms, Evidences for evolution, Adaptive radiation, Biological evolution, Hardy- Weinberg principle.
 
List of Experiments
1. To study the simple and compound microscope.
2. To study the microscopic section of the Monocot and Dicot plant.
3. To identify the part of the plant by given section (root).
4. To identify the part of the plant by given section (stem).
5. To identify the part of the plant by given section (bark).
6. To identify the part of the plant by given section (leaf).
7. To identify the part of the plant by given section (seed).
8. To identify and differentiate the parts of the given plant sample morphologically.
BPharma, PY 101(A) REMEDIAL MATHEMATICS 1st First Semester RGPV / RGTU B Pharma, PHARMACY 1st First Semester Syllabus

BPharma, PY 101(A) REMEDIAL MATHEMATICS 1st First Semester RGPV / RGTU B Pharma, PHARMACY 1st First Semester Syllabus

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RGTU/RGPV PY 101(A) REMEDIAL MATHEMATICS Syllabus
BPharma 1st sem REMEDIAL MATHEMATICS Syllabus
B. PHARMA-1st - First SEMESTER Syllabus (Modified on 27/01/11)
 
PY 101(A) REMEDIAL MATHEMATICS Course Contents:

UNIT I
Algebra: Equation reducible to quadratics, Simultaneous equations (linear and quadratic), Determinations. Properties of solution of simultaneous equations by Cramer’s rule, Matrices, definition of special kinds of matrices, arithmetic operations on matrices, inverse of a matrix. Solution of simultaneous equations by matrices, pharmaceutical applications of determinants and matrices, Evaluation on Enl, En2 and En3.

UNIT II
Menstruation and its pharmaceutical applications. Measures of Central Value objectives and pre-requisites of an ideal measure, Mean, Mode and median.

UNIT III
Trigonometry: Measurement of angle, T-ratios, addition, subtraction and transformation formulae, T-ratios of multiple, sub multiple, allied and certain angles. Application of logarithms in pharmaceutical computations.

UNIT IV
Analytical plane Geometry: Certain Co-ordinates, Distance between two points, area of triangle, a locus of points, straight line, slope and intercept form, double-intercept form, normal (perpendicular form), slope-point and two point form, general equation of first degree.

UNIT V
Calculus:
Differential: Limits and functions, definition of differential coefficient, Differentiation of standard functions including function of a function (Chain rule). Differentiation of implicit functions, logarithmic differentiation, parametric differentiation, successive differentiation.
Integral: Integration as inverse of differentiation, indefinite integrals of standard forms, integration by parts, substitution and partial fractions, formal evaluation of definite integrals.

Books & References Recommended:
1. Loney S.L., Plane Trigonomotetry.
2. Ray M., Algebra.
3. Basu K.P., Intermediate Algebra.
4. Paria G., Differential Calculus, Scholar’s Publications, Indore.
5. Paria G., Integral Calculus, Scholar’s Publications, Indore.
6. Paria G., Co-ordinate Geometry, Scholar’s Publications, Indore.
BPharma, PY 105 Pharmaceutical Chemistry II (Inorganic Chemistry) 1st First Semester RGPV / RGTU B Pharma, PHARMACY 1st First Semester Syllabus

BPharma, PY 105 Pharmaceutical Chemistry II (Inorganic Chemistry) 1st First Semester RGPV / RGTU B Pharma, PHARMACY 1st First Semester Syllabus

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RGTU/RGPV PY 105 Pharmaceutical Chemistry II (Inorganic Chemistry) Syllabus
BPharma 1st sem PY 105 Pharmaceutical Chemistry II (Inorganic Chemistry) Syllabus
B. PHARMA-1st - First SEMESTER Syllabus (Modified on 27/01/11)
 
PY 105 Pharmaceutical Chemistry II (Inorganic Chemistry) Course Contents:

1. Elements and periodicity
Modem periodic law and present form of the periodic table, s, p, d and f block elements, periodic trends in properties of elements- atomic and ionic radii, ionization enthalpy, electron gain enthalpy, valence, oxidation states and chemical reactivity.

2. Sources of impurities in pharmaceutical substances
Importance of limit test and general principles and procedure for limit tests of chloride, sulphate, iron, arsenic, lead and heavy metals.

3. Essential and Trace Elements
Study the role of essential and trace elements in biological systems and their toxicity.

Major Intra and extra cellular electrolytes: Major physiological ions, electrolytes used in replacement therapy, physiological acids-base balance, electrolytes used in acid-base therapy, electrolyte combination therapy.

4. Inorganic Agents
Occurrence, preparation, physical characteristics, chemical properties, purity test, incompatibilities, assay and pharmaceutical uses of inorganic official compounds of the following elements;
Aluminum, Sodium, Magnesium, Lithium, Calcium, Iron, Copper, Silver, Antimony, Iodine, Boran, Potassium, Zinc, Nitrogen
Reagents: Preparation, properties and uses of the following reagents; Nesslers reagent, boron trifluoride, Grignard reagent, Potassium permanganate, potassium dichromate, Hydrogen peroxide, Iodine solution.

6. Radiopharmaceuticals
Basic properties, production, quality control, stability, clinical and medicinal applications of radioisotopes used in pharmacy and medicine preparations of diagnostic and therapeutic agents.

List of Practicals
1. Limit test for Lead.
2. Limit test for Arsenic.
3. Limit test for Chloride.
4. Limit test for Sulfate.
5. Limit test for Heavy metals.
6. Standardization of sulphuric acid.
7. Standardization of hydrochloric acid.
8. Standardization of sodium hydroxide.
9. Standardization of potassium permanganate.
10. Standardization of sodium thiosulphate.
11. Determination of strength of solution of ammonia.
12. Quantitative determination of boric acid.
13. Assay of sodium bicarbonate.
14. Assay of sodium carbonate.
15. Assay of ferrous sulphate.
16. Assay of iodine solutions.
17. Preparation of Alum (potassium and ammonium).
18. Preparation of Ferrous sulfate.
19. Preparation of dibasic calcium phosphate.
20. Preparation of ferric ammonium citrate.
21. Preparation of light and heavy magnesium oxide and
22. Preparation of magnesium carbonate.
23. Preparation of calcium carbonate.
24. Preparation of magnesium trisilicate.
25. Preparation of zinc sulphate.
26. Purification of Copper sulfate.

Books Recommended
1. L.M. Atherdon, Bently and Drivers: Textbook of pharmaceutical chemistry, Oxford, University press.
2. Pharmacopoeia of India, Govt. of India, Ministry of Health, Delhi.
3. J.H. Block, E. Roche, T.O. Soine and C. O. Wilson: Inorganic Medicinal and Pharmaceutical chemistry, Lee Febiger, Philadelphia. PA.
4. Roger’s Inorganic Pharmaceutical Chemistry of Lea and Febiger, Philadelphia, USA.
5. M. Ali: Text book of Pharmaceutical Inorganic chemistry, CBS, New Delhi.
6. Mellor’s Modern Inorganic Chemistry, Longman Green and Co., Ltd., London.
7. Atkins P.W. Physical Chemistry, Oxford 1990 2.
8. Barrow G.M. Physical Chemistry, McGraw-Hill 1989
9. Beckett & Stenlake, Practical Pharmaceutical Chemistry
10. Liptrot G.F. Modern Inorganic Chemistry, Blantyre Printing
11. British Pharmacopoeia, Stationary Press, Royal Society of Pharmaceutical Press, London.
12. United State Pharmacopoeia, United State Pharmacopoeial Convention, Inc., 12601. Twinbrook Parkway, Rockyville M.D. 20852 USA.
13. Lovis F. Fiesev D.C. Experiments in Inorganic Chemistry, Health and Company, Boston.
14. Vogel Text Book of Quantitative Chemical Analysis, Longman, London.
15. Remington Practical of the Science and Pharmacy, Mack Publishing Company, Eston, Pennsylvania, USA.
BPharma, PY 604 PHARMACOGNOSY – IV 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

BPharma, PY 604 PHARMACOGNOSY – IV 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

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RGTU/RGPV PY 604 PHARMACOGNOSY – IV Syllabus
BPharma 7th sem PHARMACOGNOSY – IV Syllabus
B. PHARMA-VI 6th - Sixth SEMESTER Syllabus (Modified on 27/01/11)
 
PY 604 PHARMACOGNOSY – IV  Course Contents:


General introduction classification and brief description of different chromatographic techniques with detailed emphasis on application of paper chromatography, column chromatography, TLC, HPLC and HPTLC in the evaluation of herbal drugs.

Historical development of plant tissue culture technique, types of culture, nutritional requirements, surface sterilization of explants, growth and maintenance. Application of PTC in development of phytoconstituents.

An introduction of marine pharmacognosy and novel agents from marine sources like cardiovascular active substances, cytotoxic, antimicrobial, antibiotic, anti-inflammatory, antispasmodic agents, marine toxin etc.

Herbs as health food, cosmeceuticals.

An introduction to cultivation and utilization of aromatic plants with special reference to sandalwood oil, menthe oil, eucalyptus oil, lemon grass oil, clove oil.

Production and analysis of phytoconstituents of pharmaceutical importance like quinine, strychnine, atropine, morphine podophyllotoxin, papain, vincristine, ephedrine and Tannic acid, Spectral analysis of herbal drugs with emphasis on application of UV, IR, NMR, mass.

Natural dyes, Immunomodulators and Adaptogents.

LIST OF PRACTICAL:
1. To perform chromatography of amino acids
2. To perform paper chromatography of sugars
3. To perform TLC of alkaloids
4. To perform TLC of extract of rauwolfi, datura
5. To perform TLC of volatile oils i.e. eucalyptus oil, menthe oil
6. To identify the presence of eugenol in clove oil by TLC
7. To determine volatile oil content of eucalyptus leaf
8. To determine volatile oil content of fennel fruits
9. To isolate ammonium glycyrrhizinate from glycyrrhiza
10. To extract aloin from aloe
11. To extract tannic acid from myrobalan
12. To perform column chromatography a natural dye.

BOOKS RECOMMENDED:
1. Trease, G.E.and Evans, W.C., Pharmacognosy, Baillierc, Tindall, Eastbourne, U.K.
2. Tayler, V.E., Brady, L.R. and Robers, J.E., Pharmacognosy Lea and Febiger, Philadelphia
3. Kokate, C.K., Purohit, A.P. and Gokhale, S.B., Pharmacognosy Nirali Prakashan, Pune
4. C.R Atal and B.M. Kapoor, Cultivation & Utilization of Aromatic Plants, Council of Scientific Industrial Research (CSIR) New Delhi.
BPharma, PY 603 PHARMACEUTICAL CHEMISTRY – VII (MEDICINAL CHEMISTRY-II) 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

BPharma, PY 603 PHARMACEUTICAL CHEMISTRY – VII (MEDICINAL CHEMISTRY-II) 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

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RGTU/RGPV PY-603 PHARMACEUTICAL CHEMISTRY – VII Syllabus
RGTU/RGPV  PY-603 (MEDICINAL CHEMISTRY-II) Syllabus

PHARMACEUTICAL CHEMISTRY – VII PY-603 (MEDICINAL CHEMISTRY-II) Syllabus
B. PHARMA-VI 6th - Sixth SEMESTER Syllabus (Modified on 27/01/11)
 
PHARMACEUTICAL CHEMISTRY – VII PY-603 (MEDICINAL CHEMISTRY-II) Course Contents:


( I ) Classification and mode of action, uses, structure activity relationship including physicochemical, steric aspects and recent advances in research of the following categories of drugs:

(A) Drug Acting on CNS
  • General Anesthetics: Stages of Anesthesia , Pharmacokinetic Principles, Theories of the mechanisms.
  • Hypnotics and Sedatives : Testing and developments of new Hypnotics.
  • Antiscizure agents: Drugs effective against partial and generalized tonicclonic scizure.
  • Opiod Analgesics : Endogenous opioid peptides and their physiologic functions, Neurobiology of drug abuse and addiction.
  • Antiparkinsonian and Spasmolytic agents : Pharmacotherpy of Parkinsons disease.
  • Hallucinogens, Stimulants, and related drugs of Abuse.
  • Psychopharmacological Agents: Antipsychotic agents, Antidepressants, Anxiolytics.
(B) Drug Acting on GIT :
  • Laxative
  • Antidiarrhoeal
  • Anti spasmodic
  • Antiulcers Drugs.
(C) Drug Acting on Hormonal System:
  • Insulin and oral Hypoglycemic agents: Etiology of Diabetes, Biochemistry and Pathogenesis of Diabetes, Production of Insulin.
  • Adrenocorticoids: Mechanism of steroid Hormone action, Development of Adrenocorticoid drugs.
  • Sex Hormones: Male sex Hormones, Female sex Hormones.
  • Thyroid and Antithyroid agents : Biochemistry and Physiology of Thyroid Hormones, Biosynthesis of Thyroid Hormones.
(D) Vitamins
 
( II ) Principles of Drug Design (Theoretical Aspects). Scientific Aspects of Drug Discovery,  Preclinical Development, Mechanism based Approaches (Computer Aided Drug Design and  Molecular Modeling)

BOOKS RECOMMENDED:
1. Foye, W.C., Principles of Medicinal Chemistry, Lea and Febiger, Philadelphia.
2. Wolff , M.E. Ed., Burger’s Medicinal Chemistry, John Wiley and Sons, New York.
3. Hansch, C., Comprehensive Medicinal Chemistry, Pergarnon Press, Oxford.
4. Delagado, J.N. and Remers, W.A.R, Wilson and Giswold’s Text Book of Organic,Medicinal and Pharmaceutical Chemistry, J.Lippincott Co., Philadelphia.
5. Nogrady, T., Medicinal Chemistry-A Biochemical Approach, Oxford University Press, New York, Oxford.
6. Kar, A., Medicinal Chemistry, Willey Eastern Ltd., New Delhi. 
7. Patrick, G., An Introduction to Medicinal Chemistry, Scientific Distributors, Mumbai.
8. Malone, Dyson and Purey, May’s Chemistry of Synthetic Drugs.
9. Parimoo, P., Text Book of Medicinal Chemistry, CBS Publishers and Distributors, New Delhi.
10. Thomas, G., Introduction to Medicinal Chemistry, CBS Publishers and Distributors, New Delhi.

LIST OF PRACTICALS :
1. Synthesis and Characterization of Methylphenobarbital from Urea.
2. Synthesis and Characterization of Barbital from Urea.
3. Synthesis and Characterization of Nikethamide from Nicotinic acid.
4. Synthesis and Characterization of Pantaprazol.
5. Synthesis and Characterization of Diclofenamide.
6. Synthesis and Characterization of Phenobarbitone.
7. Synthesis and Characterization of Phenothiazine.
8. Synthesis and Characterization of Furosemide from 2,4 dichloro-benzoic acid.
9. Synthesis and Characterization of Levodopa from Vanillin.
10. Synthesis and Characterization of Sulfalene from p-aminobenzene sulphonyl chloride.
11. Synthesis and Characterization of Thioridazine.
12. Synthesis and Characterization of Chlorpromazine.
13. Synthesis and Characterization of Benorilate.
14. Synthesis and Characterization of Parbanic acid.
15. Estimation of Na+, K+, Ca++ ions using flame photometry.
16. To perform the QSAR Analysis by Free Wilson Approach.
17. To determine the regression coefficients for a series by using Hansch and Free Wilson Approach.
18. To determine the correlation between physiochemical properties and biological activity for a series by using Hansch analysis.
BPharma, PY 602 Pharmaceutical Analysis II 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

BPharma, PY 602 Pharmaceutical Analysis II 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

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RGTU/RGPV PY 602 Pharmaceutical Analysis II
BPharma 7th sem PY 602 Pharmaceutical Analysis II Syllabus
B. PHARMA-VI 6th - Sixth SEMESTER Syllabus (Modified on 27/01/11)
 
PY 602 Pharmaceutical Analysis II Course Contents:

The theoretical aspects, basic instrumentation, elements of interpretation of spectra and pharmaceutical application of the following analytical techniques –
  1. Chromatography: Paper Chromatography TLC, GLC, HPTLC and HPLC.
  2. Ultraviolet and visible spectrophotometry: Beer-lambart law, electronic transitions, instrumentation, methods, chemical derivatisation, structural analysis, applications.
  3. Infra red spectrophotometry & FT-IR: Introduction, Theory, instrumentation, interpretation of  spectra, its advantages and applications in structure elucidation. 
  4. Fluorimetry.
  5. Mass Spectroscopy: Introduction, ionization techniques, mass analyzers, fragmentation rules, instrumentation, the mass spectrum & its applications.
  6. NMR Spectroscopy: Introduction, continous-wave (CW) NMR spectrometry, pulsed fourier transform spectrometry, chemical shift, spin coupling, spin decoupling & its applications.
  7. Atomic Absorption.
  8. X- Ray Diffraction.
  9. Flame Photometry.
  10. Immunoassay techniques: Enzymes & radioimmunoassay techniques, theory, methods & its applications.

BOOKS RECOMMENDED:
  1. Svehla, G. Vogel’s Text Book of Micro and Semi Micro Qualitative Inorganic Analysis, Orient Longman, Hyderabad.
  2. Beckett, A.H. and Stenlake, J.B., Practical Pharmaceutical Chemistry, The Athlone Press of the University of London.
  3. Chatten, L.G., Text Book of Pharmaceutical Chemistry, Marcel Dekker, New York.
  4. Connors, K,.A., A Text Book of Pharmaceutical Analysis, Wiley Interscience, New York.
  5. Higuchi, J. and Hansen E.B., Pharmaceutical Analysis, Interscience Publisher John Willey and Sons, New York, Sydney.
  6. Silverstein,R.M., Bassier, G.C., and Morril,T.C., Spectrophotometric Identification of Organic Compounds, John Wiley and Sons Inc.
  7. Willard, Merritt and Settle, Instrumental Methods of Chemical Analysis,CBS Publisher and Distributors, New Delhi.
  8. Ewing, G.W., Instrumental Methods of Chemical Analysis,.

LIST OF PRACTICALS :
  1. Determination of solvent cut off value of different solvents.
  2. Study of effect of various solvents on spectral features of any drug.
  3. Perform the quantitative spectrophotometric estimation of drug by single point method.
  4. Perform the quantitative spectrophotometric estimation of drug by calibration curve method.
  5. Perform the quantitative spectrophotometric estimation of drug by standard absorptivity method.
  6. Simultaneous quantitative spectrophotometric estimation of two drugs by simultaneous equation method.
  7. Simultaneous quantitative spectrophotometric estimation of two drugs by dual wavelength method.
  8. Simultaneous quantitative spectrophotometric estimation of two drugs by derivative spectroscopy.
  9. To determine the drug content of given tablet formulation
  10. Interpretation of given IR spectra.
  11. Quantitative estimation of alprazolam (Any drug) by RP-HPLC.
  12. Simultaneous quantitative estimation of torsemide and spironolactone ( Combination of two drugs) by RP-HPLC.
  13. Acid and alkaline stress degradation study of any drug.
  14. Photo and thermal stress degradation study of any drug.
  15. Oxidative stress degradation study of any drug.
BPharma, PY-601 Pharmaceutical Industrial Management 6th (VI) Semester RGPV / RGTU B Pharma, PHARMACY 6th (VI) Semester Syllabus

BPharma, PY-601 Pharmaceutical Industrial Management 6th (VI) Semester RGPV / RGTU B Pharma, PHARMACY 6th (VI) Semester Syllabus

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RGTU/RGPV PY-601 Pharmaceutical Industrial Management Syllabus
BPharma 6th sem PY-601 Pharmaceutical Industrial Management Syllabus
B. PHARMA-VI 6th - Sixth SEMESTER Syllabus (Modified on 27/01/11)

PY-601 Pharmaceutical Industrial Management Course Contents:

Status of pharmaceutical industries in India.
Project formulation, evaluation and implementation.
Pharmaceutical Factory Planning and layouts, preparation of flow diagrams, technical data sheets.

Pharmaceutical Management :
Concepts on Management, Principles of Management, Administrative and Operative Management Enterpreneurship Development.
Material management: Basic principles of Material Management, Purchase, Store and Inventory control.

Pharmaceutical Production Management :
Different aspects of Production Management , Performance Evaluation Technique, flow-process, know how process and maintainence.
Accountancy: Principles of accountancy, Journal entries and ledger posting, preparation of trial balance, cash book, bank reconciliation statement, rectification of errors, profits and loss account, balance sheet, purchase, keeping and pricing of stocks, treatment of cheques, bill of exchange, promissory notes and hundies, documentary bills.

Pharmaceutical Economics:
Principles of economics with special reference to the laws of demands and supply, demand schedule, demand curves, general principles of insurance and inland and foreign trade, procedure of exporting and importing goods.
Pharmaceutical Marketing: Functions, wholesale, retail, and mail order business ,market research.

Pharmaceutical Salesmanship:
Principles of sales promotion, advertising, and ethics of Sales, merchandising, Window display and literature detailing.

BOOKS RECOMMENDED:
1. Shukla, S. M., Advanced Accountancy, Mahershwari Sahitya Bhawan, Agra.
2. Gupta, R. L., Advanced Accountancy, Vol. I and II, Sultanchand & Company, New Delhi.
3. Kotler, P., Marketing Management, Prentice Hall of India Limited.
4. Stanton, W. J., Fundamentals of Marketing Tata McGraw Hill Limited, New Delhi.
5. Buskir K. and Richard H., Principles of Marketing – The Management View, Hold Rinehard and Winston Incorporated, New York.
6. Sherlekar, S. R., Marketing Management, Himalaya Publishing House, New Delhi.
7. Mote,V. L., Paul, S. and Gupta, G. S., Managerial Economics Concepts and Cases, Tata McGraw Hill Limited, New Delhi.
BPharma, PY 605 Pharmacology-II 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

BPharma, PY 605 Pharmacology-II 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

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RGTU/RGPV PY 605 Pharmacology-II Syllabus
BPharma 7th sem Pharmacology-II Syllabus
B. PHARMA-VI 6th - Sixth SEMESTER Syllabus (Modified on 27/01/11)
 
PY 605 Pharmacology-II Course Contents:


Pathophysiology of diseases of cardiovascular system and pharmacology of drugs used for their treatment
a) Cardiac Glycosides
b) Antiarrythmic drugs
c) Antianginal drugs
d) Antihypertensive drugs

Pharmacology of drugs acting on hematopoietic system
a) Hematinics
b) Drugs affecting coagulation, bleeding and thrombosis
c) Plasma expanders
d) Hypolipidaemic drugs

Pharmacology of drugs acting on urinary system

Pathophysiology of diseases of endocrine system and pharmacology of drugs used for their treatment

a) Hypothalamic and pituitary hormones
b) Thyroid hormones and antithyroid drugs
c) Insulin, oral hypoglycemic agents and glucagons
d) Corticosteroids
e) Androgens and drugs for erectile dysfunction
f) Estrogens, progestins and contraceptives
g) Oxytocin and drugs acting on uterus
h) Drugs affecting calcium balance

List of Practicals
1. Determine the strength of given sample (acetyl choline/ histamine) by three point bioassay method using isolated organ preparation (rat ileum/ rat duodenum/ rat colon/ rat fundus/ guinea pig ileum).
2. Determine the strength of given sample (acetyl choline/ histamine) by four point bioassay method using isolated organ preparation (rat ileum/ rat duodenum/ rat colon/ rat fundus/ guinea pig ileum).
3. Record the concentration response curve of oxytocin using rat uterus preparation.
4. Determine the sympatholytic activity of given drug sample using isolated guinea pig ileum preparation.
5. Compare the diuretic/saluretic activity of different drugs in rats.
6. Determine the effect of anticoagulants by subaqueous tail bleeding time method in rodents.
7. Study the effect of oral hypoglycemic agents in diabetic rodents.
8. Study the effect of thyroid hormones on the tensile strength of connective tissues in rats.
9. Study the effect of growth hormone on the weight gain in female rats.

BOOKS RECOMMENDED
1) Herfindal, E.T., Gourley, D.R., (eds.) (2000) Textbook of therapeutics Drug and disease management. 7th ed. Baltimore: Lippincott Williams and Wilkins
2) Hardmen, J.G., Limbird, L.E., Gilman A.,G., (eds.) (2001) Goodman and Gilman’s The pharmacological basis of therapeutics. 10th ed. USA: The McGraw Hill Companies
3) Kumar, V., Abbas, A.K., Fausto, N., (eds.) (2004) Robbins and Cotran Pathologic basis of disease. 7th ed. Pennsylvania: Saunders
4) Barar, F.S.K., (2000) Essentials of therapeutics. New Delhi: S. Chand and Company (P) Ltd.
5) Satoskar, R.S., Bhandarkar, S.D., Rege, N.N., (2007) Pharmacology and Pharmacotherapeutics. 12th ed. Mumbai: Popular Prakashan
6) Seth, S.D., (ed.) (2005) Textbook of Pharmacology. 2nd ed. New Delhi. Elsevier
7) Tripathi, K.D. (1999) Essentials of medical pharmacology. 4th ed. New Delhi: Jaypee Brothers Medical Publishers (P) Ltd.
8) Rang, H.P., et al. (eds.) (2003) Pharmacology. 5th ed. Philadelphia: Elsevier
9) Katzung, B.G., (2004) Basic and clinical pharmacology. 9th ed. USA: The McGraw Hill Companies.
10) Pillai, K.K., (2009) Experimental Pharmacology. New Delhi, CBS Publishers and Distributers.
11) Kulkarni, S.K., (2005) Handbook of Experimental Pharmacology. New Delhi, Vallabh Prakashan.
12) Vogel, H.G., (ed.) (2002) Drug Discovery and Evaluation. Pharmacological Assays. 2nd Ed. Heidelberg, Germany, Springer-Verlag.
BPharma, PY-701 PHARMACEUTICS VIII (PHARMACEUTICAL TECHNOLOGY I) 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

BPharma, PY-701 PHARMACEUTICS VIII (PHARMACEUTICAL TECHNOLOGY I) 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

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RGTU/RGPV PY-701 PHARMACEUTICS VIII Syllabus
RGTU/RGPV (PHARMACEUTICAL TECHNOLOGY I) Syllabus PHARMACEUTICS VIII (PHARMACEUTICAL TECHNOLOGY I) Syllabus
BPharma Pharmcy 7th - Seventh Semester Syllabus

PY-701 PHARMACEUTICS VIII (PHARMACEUTICAL TECHNOLOGY I) Course Contents:


Formulation considerations, technology involved, equipment (machine) employed, problems to be ncountered, packaging evaluation and CMP (India, WHO & USFDA) requirements of the following dosage forms.
1. Solid Dosage Forms- Tablets, Tablet coatings and Capsules.
2. Liquid Dosage Forms- Liquid Orals, Dry Syrups.
3. Semisolid Dosage Forms- ointments, Creams, Suppositories, Gels.
4. Sterile Dosage Forms- Parenteral ( Small Volume Parenterals & Large Volume Parenterals ) and
ophthalmic Preparations.
5. Pharmaceutical Aerosols

Blood Products and Plasma Substitutes:
Collection, processing and storage of whole human blood, concentrated human RBC, dried human plasma, human normal immunoglobulin, plasma substitutes, ideal requirements, PVP, Dextran, etc. for control of blood pressure,

Surgical products:
Definition, surgical cotton, surgical gauzes, bandages, adhesive tapes, absorbable and non absorbable sutures, ligatures and catguts, Medical prosthetics and organ replacement materials.

Books Recommended
1. Rawlins, E.A., Text Book Of Pharmaceutics, Bailliere Tindall.
2. Lachman, L. , Liberman, H.A. and Kanig, J.L., The Theory and Practice of Industrial Pharmacy, Lea and Febiger, Philadelphia.
3. Liberman, H.A., lachman, L. and Ker Inc. New York.
4. Pharmacopoeia Of India, Ministry of Health and family Welfare, Govt. of India, New Delhi.
5. Avis, K.E., Lachman, L. and Liberman, H.A., Pharmaceutical Dosage Forms-Parenteral Medication Vol.1-2, Marcel Decker Inc., New York.
6. Banker G.S. and Rhode C.T., Modern Pharmaceutics, Marcell Decker Inc., New York.
7. Bean, H.S., Beckett, A.H. and Carless, A.H., Advances in Pharmaceutical Sciences, Vol.1-4,
Academic Press, London.
 
B.Pharm. Semester VII PY-701:Pharmaceutics-VIII Pharmaceutical Technology –I

List of Practicals

1. Prepare and evaluate Paracetamol Compressed Tablets.
2. Prepare and evaluate Effervescent Tablets of Aspirin.
3. Prepare and evaluate Dispersible tablets of Diclofenac Sodium.
4. Perform the Sugar Coating on the given sample of Tablets.
5. Perform the Film Coating on the given sample of Tablets.
6. Perform the Enteric Coating coating on the given sample of Tablets.
7. Prepare and evaluate Tetracycline HCL Capsules.
8. Prepare and evaluate Antacid Suspension.
9. Prepare and evaluate B-Complex Syrup.
10. Prepare and evaluate Amoxicillin Dry Syrup.
11. Prepare and evaluate Castor Oil Emulsion.
12. Prepare and evaluate Diclofenac Sodium Suppositories.
13. Prepare and evaluate Vaporizing Ointment.
14. Prepare and evaluate Non-Staining Iodine Ointment containing Methyl Salicylate.
15. Prepare and evaluate Antiseptic Cream.
16. Prepare and evaluate Diclofenac Gel.
17. Prepare and evaluate Ciprofloxacin Eye Drop.
18. Prepare and evaluate Water for Injection.
19. Prepare and evaluate Oxytetracycline Injection.
20. Perform the Sability Studies of given sample of Paracetamol Tablets.
21. Prepare and evaluate an aqueous injection of a poorly water – soluble drug using hydrotropic solubilization technique.
BPharma, PY702 : Pharmaceutics-X (Biopharmaceutics and Pharmacokinetics) 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

BPharma, PY702 : Pharmaceutics-X (Biopharmaceutics and Pharmacokinetics) 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

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RGTU/RGPV PY702 : Pharmaceutics-X Syllabus
RGTU/RGPV (Biopharmaceutics and Pharmacokinetics) Syllabus 
BPharma 7th sem PY702 : Pharmaceutics-X (Biopharmaceutics and Pharmacokinetics) Syllabus
BPharma 7th - Seventh Semester Syllabus

PY702 : Pharmaceutics-X (Biopharmaceutics and Pharmacokinetics) Course Contents:

Introduction to biopharmaceutics and pharmacokinetics development and their role in drug formulation.

Biopharmaceutics
Definition , passage of drugs across biological barrier , Physiochemical , Biological and Pharmacaceutical factors influencing biopharmaceutical performance of drugs.
  1. Gastrointestinal absorption of drugs: Passage of drugs across biological membranes, nature of biological membranes, gastrointestinal absorption mechanisms.
  2. Factors affecting drug absorption : Physiological factors, dietary factors,physiochemical factors, pH partition hypothesis, dosage form factors.
  3. Methods of studying gastrointestinal absorption: In vitro and in vivo methods.
  4. Drug disposition: Distribution in blood, cellular distribution, plasma protein binding, tissue protein binding.
Drug Excretion: Routes of drug excretion, renal excretion of drugs, factors affecting renal excretion, biliary and salivary excretion of drugs.
Drug biotransformation: Pathways of drug metabolism, drug metabolizing enzymes, factors affecting drug metabolism and drug response, inhibition and stimulation of drug metabolism.
 
Pharmacokinetics
Absorbtion, distribution metabolism and excretion of drugs, fluid compartment and circulatory system, protein binding, significance of plasma drug concentration measurement.

Compartment Models
Model selection criteria, alaika information criterian, one – compartment and two compartment models, Wagner- Nelson and loo Riegelman methods for estimation of absorption constants. Curve fittings,regression procedure and area under blood level curves.

Clinical Pharmacokinetics
Urinary excretions, computation of pharmacokinetic parameters from urine data, haepetic clearance,biliary excretion,excretion ratio,dosage regimen adjustment in patients with and without renal failure, pharmacokinetic drug interaction and their significance in combination therapy.

Biovailability and Bioequivalance
Biovailability and Bio-equivalance, Federal requirements, Methods of determination of bioavailability using blood level and urinary excretion data, design and evaluations, bioavailability assessment.

Books recommended
1. Gibaldi, M.and Perrier d, Pharmacokinetics, 4th edn. Pharma mid press, Hydrabad
2. Notari, R.E., Biopharmaceutics and pharmacokinetics-An Introduction, marcel Decker New York.
3. Jaiswal , Brahmankar Biopharmaquality and pharmacokinetics.
4. Leepeter I.D., Pharmacokinetic analysis
5. Niazi Textbook of Biopharmacokinetics and clinical pharmacokinetics.
6. Venkaateshwaru v , Biopharmaceutics and pharmacokinetics, phared puss, Hydrabad.
7. Wagner-pharmacokinetics for the pharmastudies.
8. Dhachinamoorthi D: Biopharmaceutics and pharmacokinetics : A practical mannd
9. Shargel : pharmacokinetics & Biopharmacokinetics & Biopharmaceutics

B.Pharm. Sem–VII PY 702 : Pharmaceutics–X (Biopharmaceutics & pharmacokinetics ) practicals
 
List of Practicals
1. Determine the percentage protein binding of the given drug.
2. Determine oral bioavailability of the given drug/formulation by urinary excretion method using animal model.
3. Perform bioequivalence study of two different brands of the marketed tablets of the given drug using animal model.
4. Determine the rate of in-vitro absorption of the given drug using everted intestinal sack.
5. Determine the effect of different pH condition on solubility of a weekly acidic or basic drug and study PH partition hypothesis.
6. Establish IVIVC for the given sample of drug.
7. Calculate elimination rate constant and elimination half life of given excretion data by sigma minus
method.
8. Calculate elimination rate constant and elimination half life of the given drug data administered by i.v. bolus injection represented by one compartment model.
9. Calculate various pharmacokinetic parameters from the given data generated after single extra vascular administration of drug represented by one compartment model.
10. Calculate various pharmacokinetic parameters from the given data obtained by using two compartment open model.
BPharma, PY - 703 : PHARMACEUTICAL CHEMISTRY VIII (MEDICINAL CHEMISTRY-III) 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

BPharma, PY - 703 : PHARMACEUTICAL CHEMISTRY VIII (MEDICINAL CHEMISTRY-III) 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

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RGTU/RGPV  PY - 703 : PHARMACEUTICAL CHEMISTRY VIII Syllabus
RGTU/RGPV  (MEDICINAL CHEMISTRY-III) Syllabus
PY - 703 : PHARMACEUTICAL CHEMISTRY VIII (MEDICINAL CHEMISTRY-III)
BPharma 7th - Seventh Semester Syllabus

PY - 703 : PHARMACEUTICAL CHEMISTRY VIII (MEDICINAL CHEMISTRY-III)  Course Contents:

The synthesis of the selected drugs, mode of action, classification, uses, SAR of the following category of drugs:

Drugs acting on Cardiovascular system :
  • Cardiac Glycosides
  • Antiarrythmic drugs
  • Antianginal drugs
  • Antihypertensive drugs
  • Antihyperlipidimic drugs
Drugs acting on Urinary system :
  • Diuretics
Chemotherapeutic Agents
  • Anti metabolites(Including Sulpha durgs)
  • Anti viral & Anti HIV,
  • Anti neoplastic,
  • Anti malarials,
  • AntiProtozoal
  • Anti tubercular,
  • Anthelmintics,
  • Antifungals
  • B-lactum antibiotics
  • Aminoglycosides
  • Protein synthesis inhibitors (Tetracyclins,chloramphenicol,Macrolides)
  • Miscellaneous antibiotics (Bacitracin, Glycopeptides, Polymyxins)
  • Immuno- suppressive
Drugs affecting uterine motility
  • Oxytocins (including prostaglandins and Ergot alkaloids).
Books Recommended:
1. Foye, W.C., Principles of Medicinal Chemistry, Lea and Febiger, Philadelphia.
2. Wolff , M.E. Ed., Burger’s Medicinal Chemistry, John Wiley and Sons, New York.
3. Hansch, C., Comprehensive Medicinal Chemistry, Pergarnon Press, Oxford
4. Delagado, J.N. and Remers, W.A.R, Wilson and Giswold’s Text Book of Organic,Medicianl and Pharmaceutical Chemistry, J.Lippincott Co., Philadelphia.
5. Nogrady, T., Medicinal Chemistry-A Biochemical Approach, Oxford University Press, New York, Oxford.
6. Kar, A., Medicinal Chemistry, Willey Eastern Ltd., New Delhi.
7. Patrick, G., An Introduction to Medicinal Chemistry, Scientific Distributors, Mumbai.
8. Malone, Dyson and Purey, May’s Chemistry of Synthetic Drugs.
9. Parimoo, P., Text Book of Medicinal Chemistry, CBS Publishers and Distributors, New Delhi.
10. Thomas, G., Introduction to medicinal Chemistry, CBS Publishers and Distributors, New Delhi.
11. Sten lake B.J. medicinal and pharm. Chemistry pharma mid press, Hyderabad
BPharma, PY704 : Pharmaceutical Biotechnology Theory 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

BPharma, PY704 : Pharmaceutical Biotechnology Theory 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

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RGTU/RGPV PY704 : Pharmaceutical Biotechnology Theory Syllabus
BPharma 7th sem PY704 : Pharmaceutical Biotechnology Theory Syllabus
BPharma 7th - Seventh Semester Syllabus

PY704 : Pharmaceutical Biotechnology Theory Course Contents:

Historical Development :

Immunology and Immunological Preparations :
Principles, Antigens and antibodies, Antigen-antibody reactions and their applications, Immune system.Cellular humoral immunity, Immunological tolerance, Hypersensitibity, Immunological and diagnostic preparations: Methods of their preparation, standardization and storage.

Enzyme Immobilization –
Techniques of Immobilization of enzymes, Kinetics and factors affecting enzymes kinetics, Enzymes based sensors, Study of enzymes such as Hyaluronidase, Penicillinase, Strepto- Kinase, Amylases etc. Immobilization of bacteria and plant cells, Applications of Immobilization.

Genetic Recombination :
Transformation, Conjugation, Transduction, Protoplast fusion, Gene cloning and their applications, Monoclonal antibodies and hybridoma technology, Recombinant DNA technology: Concepts, Methodology and Pharmaceutical applications. Study of drugs produced by biotechnology such as Activase, Humulin, Humatrope, Introne A, Monoclate, Orthoclone OKT3, Referon-A, Recombivax HB etc.Drug delivery systems in Gene therapy.

Microbiological Transformation –
Intoduction, Types of reactions mediated by micro organisms. Design of biotransformation processes, Selection of organism, Biotransformation processes and its improvements with special refrence to steroids.

Industrial Biotechnology –
Historical development, Fermenter and its design, Control of different parameters in fermentation process, Isolation of mutants, Use of mutagenic agents, Factors in influencing rate of mutation. Design of fermentation process, Fermentative, production of Alcohol, Acetic acid, Penicillin, Streptomycin, Riboflavin, Vitamin B12.

B.Pharm. Semester- VII PY 704 Pharmaceutical Biotechnology Practical

List of Practicals
1. Detect the presence of the amylase enzyme in saliva.
2. Isolate the DNA from cauliflower.
3. Perform VDRL test for the given sample of blood.
4. Isolate the phospholipid from egg yolk .
5. Perform WIDAL test for the given sample of blood.
6. Perform DOT ELISA test of the given sample of blood.
7. Isolate the total RNA from yeast tablet.
8. Immobilize the given enzyme by adsorption method using calcium alginate beads.
9. Perform titre value of antibody in given blood sample.
BPharma, PY -705 : Pharmacology – IV 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

BPharma, PY -705 : Pharmacology – IV 7th (VII) Semester RGPV / RGTU B Pharma, PHARMACY 7th (VII) Semester Syllabus

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RGTU/RGPV PY -705 : Pharmacology – IV Syllabus
BPharma 7th sem PY -705 : Pharmacology – IV Syllabus
BPharma 7th - Seventh Semester Syllabus

PY -705 : Pharmacology – IV Course Contents:

Chemotherapy of Microbial Diseases
  • General principles
  • Synthetic organic antimicrobials (Sulphonamides, quinolones etc.)
  • B-lactum antibiotics
  • Aminoglycosides
  • Protein synthesis inhibitors (Tetracyclins,chloramphenicol,Macrolides)
  • Antitubercular drugs, antileprotic drugs,antiprotozoals, anthelmintics, antifungals
  • Antiretroviral and antiviral drugs
  • Miscellaneous antibiotics (Bacitracin, Glycopeptides, Polymyxins)
Chemotherapy of cancer and immunosuppressive agents
 
Basic concepts of Pharmacotherapy
  • Individualization of drug therapy : Clinical pharmacokinetic and pharmacodynamics
  • Drug use during pregnancy, Pediatrics and Geriatrics
  • Adverse drug reactions and drug induced diseases
  • Drug interactions
  • Therapeutic drug monitoring
Clinical Toxicology
  • Definition of poison
  • General principles of treatment of poisoning
  • Treatment of opioid, barbiturate, organophosphorous, and atropine poisoning
  • Heavy metals and heavy metal antagonists
BOOKS RECOMMENDED
1) Herfindal, E.T., Gourley, D.R., (eds.) (2000) Textbook of therapeutics Drug and disease management.7th ed.Baltimore : Lippincott Williams and Wilkins
2) Hardmen, J.G.Limbird, L.E. Gilman A., G., (eds.) (2001) Goodman and Gilman’s The pharmacological basis of therapeutics. 10th ed. USA : The McGraw Hill Companies
3) Barar, F.S.K., (2000) Essential of therapeutics. New Delhi: S. Chand and Company (P) Ltd.
4) Satoskar, R.S. Bhandarkar, S.D., Rege, N.N., (2007) Pharmacology and Pharmacotherapeutics. 12th ed. Mumbai: Popular Prakashan
5) Seth, S.D., (ed.) (2005) Textbook of Pharmacology. 2nd ed. New Delhi. Elsevier.
6) Tripathi, K.D. (1999) Essentials of Medical pharmacology. 4th ed. New Delhi : Jaypee Brothers Medical Publishers (P) Ltd.
7) Rang, H.P., et. (eds.) (2003) Pharmacology. 5th ed. Philadelphia Elsevier.
8) Katzung , B.G., (2004) Basic and clinical pharmacology. 9th ed. USA : The Mcgraw Hill Companies.
9) Dipiro, J.T., et al. (eds.) (1997) Pharmacotherapy. A pathophysiologic approach. 3rd ed. Stanford, Connecticut: Appleton and Longe.
10)Craig, C.R., Stitzel, R.E. (1999) Modern pharmacology with clinical applications. 5th ed. USA.
11) Guideliness for poison control. (1999) WHO, Geneva: AITBS Publisher, Delhi
12) Curry – Drug disposition and pharmacokinetics with a consideration of pharmacokinetics with a consideration of pharmacological and elinical relationships, 3rd edn., pharmumed pre
13) Kenakin Terry P: A pharmacological Primer – theory applications & methods, pharma med prre
BPharma, 5th (V) Sem PHARMACEUTICS- VI PY-501(COSMETIC TECHNOLOGY)RGPV / RGTU B Pharma, PHARMACY 5th (V) Semester Syllabus

BPharma, 5th (V) Sem PHARMACEUTICS- VI PY-501(COSMETIC TECHNOLOGY)RGPV / RGTU B Pharma, PHARMACY 5th (V) Semester Syllabus

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RGTU/RGPV PHARMACEUTICS- VI PY-501(COSMETIC TECHNOLOGY)
PY-501 PHARMACEUTICS- VI BPharma 5th sem Syllabus
COSMETIC TECHNOLOGY- BPharma 5th sem Syllabus
BPharma 5th - Fifth Semester Syllabus

B. PHARMA- V SEMESTER (Modified on 14/06/10) Effective for 2008 – 2009 Batch

PHARMACEUTICS- VI PY-501(COSMETIC TECHNOLOGY) Course Contents:

Fundamental of cosmetic science. Structure and functions of skin and hair. Formulation considerations, preparation, packaging and evaluation of the following categories of cosmetics-
  • Face Preparation: Face powder, Compact powder, Talcum powder, Face packs and Masks.
  • Skin Preparation: Skin creams, Anti-wrinkle preparations, Barrier materials, Protective creams and gels, Vanishing creams, Cold creams, Cleansing creams, all purpose creams, emollient, Anti-perspirant,/ deodorant, Moisturising and foundation formulation. Bleaching creams, Night and Massage creams, Hand creams, Protective skin tonics, Skin moisturizers, Sun-screen, Suntan, and anti-sun burn preparation.
  • Shaving Preparation: Lather shaving stick, Lather shaving creams, Shaving foams, Shaving gels, Pre-and After shave lotions.
  • Shampoo and Bath preparations: Clear liquid shampoos. Aerosol shampoos, dry shampoos, Acid-balanced shampoos, Egg shampoos, Anti-dandruff Shampoos, Bath oils, Foam baths.
  • Hair Preparations: Hair tonics, Hair conditioners, Hair lotions, Hair sprays, Hair dressings, Hair setting lotions and creams, Hair dyes, Bleaches, Hair waiving, Hair straightners and Hair strengthners.
  • Dentrifice: Tooth powders, Tooth pastes, Denture cleansers.
  • Foot Preparation: Foot powders, Foot sprays, Foot creams, Corn preparations and Athelete’s foot preparation.
  • Manicure Preparation: Nail polish, Nail lacquers and Nail bleaches.
  • Herbal Cosmetics: Cosmetics containing Aloe, Babul, Brahmi, Chandan, Cucumber, Haldi, Jatamansi, Khus, Mehandi, Neem, Reetha, Shikakai, Tulsi, Arnica, Bhringraj and Volatile oils .
  • Cosmetic for babies.
  • Colored make-up preparations: Lipsticks, Rouge, Mascara, Eye make-up, Eye-liner, Eyebrow pencils.
LIST OF PRACTICALS:
1. Prepare, Pack and Evaluate Compact Powder.
2. Prepare and Pack Face Mask.
3. Prepare and Evaluate Talcum Powder.
4. Prepare and Evaluate Vanishing Cream.
5. Prepare and Evaluate Cold Cream.
6. Prepare and Evaluate Cleansing Cream.
7. Prepare and Evaluate Emollient Cream.
8. Prepare and Evaluate Sunscreen preparation.
9. Prepare and Evaluate After shave lotion.
10. Prepare and Evaluate Lather shaving cream.
11. Prepare and Evaluate Simple shampoo (Soap based).
12. Prepare and Evaluate Acid balanced shampoo.
13. Prepare and Evaluate Egg shampoo.
14. Prepare and Evaluate Anti-dandruff Shampoo.
15. Prepare and Evaluate Hair conditioner.
16. Prepare and Evaluate Tooth Powder.
17. Prepare and Evaluate Tooth Paste.
18. Prepare, Pack and Evaluate Lipsticks.
19. Prepare, Pack and Evaluate Nail lacquer.
20. Prepare and submit Herbal preparations. (Atleast 5 different types)
BOOKS RECOMMENDED:
1. M. S. Balsam & Edward Sagarin (Eds.), Cosmetic Science and Technology, Vol. 1-3, Krieger Publishing company. Florida.
2. Mac Chesney, J. C., Packaging of Cosmetic an Toiletries, Newness- Butterworth, London.
3. E.G., Thomssen, Modern Cosmetics, Universal Publishing Corporation, Bombay.
4. Jellinek, J.S. Formulation and Functions of Cosmetics, John Willey & Sons, New York.
5. R. K . Nema, K. S. Rathode, B.K. Dubey, Text Book of Cosmetics, CBS- Publishers & distributors, New Delhi.
6. Sunil Nanda, Arun Nanda & R.K. Khar, Cosmetic Technology, Birla publications Pvt. Ltd., Delhi.
7. B. M. Mithal and R.N. Saha, A handbook of cosmetics, Vallabh Prakashan, Delhi.
8. P.P. Sharma, Cosmetics- Formulation, Manufacturing & Quality control,Vandana Publications Pvt. Ltd, Delhi.
9. Hildo Butler (Ed.), Poucher’s Perfumes, Cosmetics & Soaps, Kluwer Academic Publishers, The Netherland.
10. S.C. Bhata, Perfumes, soaps, Detergents and Cosmetics Vol. 1 & 2, CBS Publishers and Distributors, New Delhi.
11. Drug and Cosmetics Act & Rules.
BPharma, 5th (V) Semester PY-505 PHARMACOLOGY-II RGPV / RGTU B Pharma, PHARMACY 5th (V) Semester Syllabus

BPharma, 5th (V) Semester PY-505 PHARMACOLOGY-II RGPV / RGTU B Pharma, PHARMACY 5th (V) Semester Syllabus

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RGTU/RGPV PY-505 PHARMACOLOGY-II Syllabus
PY-505 PHARMACOLOGY-II BPharma 5th sem Syllabus
BPharma 5th - Fifth Semester Syllabus

Effective for 2008 – 2009 Batch B. PHARMA- V SEMESTER (Modified on 14/06/10)

PY-505 PHARMACOLOGY-II Course Contents:

Pathophysiology of CNS diseases and pharmacology of drugs used to treat them
 
1) Neurohumoral transmission in CNS
  • a. Cholinergic pathways
  • b. Dopaminergic pathway
  • c. Serotonergic pathways
  • d. Noradrenergic pathways
2) General anesthetics
3) Hypnotics, sedatives, antianxiety agents, and centrally acting muscle relaxants.
4) Psychopharmacological agents
  • a. Antipsychotics
  • b. Antidepressants
  • c. Antimaniacs
  • d. Hallucinogens
5) Anti-epileptic drugs
6) Narcotic analgesics and antagonist
7) Drugs used in neurodegenerative diseases
  • a. Parkinson’s Disease
  • b. Alzheimer’s Disease
8) Drug addiction and drug abuse
  • a. Alcohol
  • b. Nicotine
  • c. Cannabis
9) CNS stimulants

Pharmacology of drugs acting on gastrointestinal tract
1) Antacids, antisecretory and antiulcer drugs
2) Emetics and antiemetics

LIST OF PRACTICALS 
  1. Bioassay for acetylcholine/histamine using isolated organ preparations (rat ileum/rat duodenum/rat colon/rat fundus/guinea pig ileum/guinea pig tracheal chain preparation/goat ileum)  ( a) Matching bioassay or Bracketing bioassay (b) Interpolation bioassay or graphical bioassay
  2. Study the CNS depressants using cornea and pinna reflex test.
  3. Study CNS stimulants by evaluation of locomotor activity (Actophotometer)
  4. Study Central muscle relaxants using Rota rod apparatus
  5. Study lenticular opacity produced by opioid analgesics in rodents.
  6. Study anticonvulant effect of some drugs using maximum electroshock method and chemical-induced convulsion method.
  7. Study antianxiety effect of some drugs using elevated plus maze test or social interaction test or novelty suppressed feeding test in rodents.
  8. Evaluate hypnotic activity of a drug by employing potentiation of thiopental induced
  9. sleeping time paradigm.
  10. Study antipsychotic effect of some drugs using catalepsy test or inhibition of amphetamine stereotypy in rodents. Study intravenous anesthetics using righting reflex test. 
BOOKS RECOMMENDED
1) Herfindal, E.T., Gourley, D.R., (eds.) (2000) Textbook of therapeutics Drug and disease management. 7th ed. Baltimore: Lippincott Williams and Wilkins
2) Hardmen, J.G., Limbird, L.E., Gilman A.,G., (eds.) (2001) Goodman and Gilman’s The pharmacological basis of therapeutics. 10th ed. USA: The McGraw Hill Companies
3) Kumar, V., Abbas, A.K., Fausto, N., (eds.) (2004) Robbins and Cotran Pathologic basis of disease. 7th ed. Pennsylvania: Saunders
4) Barar, F.S.K., (2000) Essentials of therapeutics. New Delhi: S. Chand and Company (P) Ltd. 
5) Satoskar, R.S., Bhandarkar, S.D., Rege, N.N., (2007) Pharmacology and
Pharmacotherapeutics. 12th ed. Mumbai: Popular Prakashan
6) Seth, S.D., (ed.) (2005) Textbook of Pharmacology. 2nd ed. New Delhi. Elsevier
7) Tripathi, K.D. (1999) Essentials of medical pharmacology. 4th ed. New Delhi: Jaypee Brothers Medical Publishers (P) Ltd.
8) Mycek M.J., Haney, R.A., Champe, P.C. (2000) Lippincott’s illustrated reviews: Pharmacology. 2nd ed. Baltimore: Lippincott Williams and Wilkins.
9) Rang, H.P., et al. (eds.) (2003) Pharmacology. 5th ed. Philadelphia: Elsevier
10) Katzung, B.G., (2004) Basic and clinical pharmacology. 9th ed. USA: The McGraw Hil Companies.
11) McKim, W.A., (2006) Drugs and Behavior: An Introduction to Behavioral Pharmacology. London: Prentice Hall.
BPharma, 5th (V) Semester PHARMACOGNOSY -III PY-504 RGPV / RGTU B Pharma, PHARMACY 5th (V) Semester Syllabus

BPharma, 5th (V) Semester PHARMACOGNOSY -III PY-504 RGPV / RGTU B Pharma, PHARMACY 5th (V) Semester Syllabus

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RGTU/RGPV PY-504 PHARMACOGNOSY -III
PHARMACOGNOSY -III BPharma 5th sem Syllabus
BPharma 5th - Fifth Semester Syllabus

Effective for 2008 – 2009 Batch B. PHARMA- V SEMESTER (Modified on 14/06/10)
PY-504 PHARMACOGNOSY -III  Course Contents:

  • General techniques of biosynthetic studies and basic metabolic pathways. Introduction to biosynthesis of secondary metabolites of pharmaceutical importance. A brief introduction of chemical nature of phytoconstituents.
  • Radio – tracer techniques and utilization in biogenetic studies.
  • Phytochemical Screening: Preparation of extracts and different tests performed for screening of extracts for the presence of alkaloids, saponins, steroidal compounds, flavanoids, anthraquinones, phenolics, amino acids, carbohydrates, fats etc.
  • Concepts of stereoisomerisms Nature, distribution, classification, general methods of isolation and properties of alkaloids and terpenoids.
  • Chemistry, biogenesis and pharmacological activity of atropine, reserpine, ephedrine, ergometrine, strychnine, quinine, morphine, digitoxin, sennosides, diosgenin, sarsapogenin, menthol, citral, taxol, rutin and artemisine.
  • Systematic pharmacognostical study of alkoloidal drugs like; Tobacco, Belladona, Hyoscyamus, Datura, Coca, Withania, Cinchona, Ipecac, Opium, Ergot, Rauwolfia, Vinca, Nuxvomica, Physostigma, Pilocarpus, Veretrum, Kurchi, Ephedra, Solanam, Tea, Colchicum, coffeae, aconite etc.
LIST OF PRACTICALS:
1. Identify Colchicum, Ipecac and Vinca leaves morphologically.
2. Identify Aconite, Hyoscyamus and Withania leaves morphologically.
3. Perform morphological, microscopic and chemical evaluation of Tobacco.
4. Perform morphological, microscopic and chemical evaluation of Withania.
5. Perform morphological, microscopic and chemical evaluation of Cinchona bark.
6. Perform morphological, microscopic and chemical evaluation of Rauwolfia root.
7. Perform morphological, microscopic and chemical evaluation of Nux vomica seeds.
8. Perform morphological, microscopic and chemical evaluation of Ephedra.
9. Perform morphological, microscopic and chemical evaluation of Kurchi bark.
10. Isolate Nicotine from tobacco.
11. Isolate Caffeine from tea leaves.
12. Isolate Quinine from cinchona.
13. Isolate alkaloids from nux vomica seeds.
14. Isolate starch from potatoes.
15. Perform morphological characterization like type of stomata and calculate the stomatal index, vein islets, vein termination numbers, microscopic and chemical evaluation of Datura leaves.
16. To identify and evaluate the given sample of Colchicum corm by morphological, microscopical and chemical evaluation.
17. To identify the given sample of powdered crude drug by various phytochemical tests. (Cinchona/Rauwolfia/Senna/Ephedra)

BOOKS RECOMMENDED
1. Trease, G.E. and Evans, W.C., Pharmacognosy, Bailliere Tindall, Eastbourne, U.K.
2. Tayler, V.C., Brady, L.R. and Robers, J.E., Pharmacognosy, Lea and Febiger, Philadelphia.
3. Shah, C.S. and Quadry, J.S., A text book of Pharmacognosy, B.S. Shah Publishers, Ahmedabad.
4. Kokate, C.K., Purohit, A.P. and Gokhale, S.B., Pharmacognosy, Nirali Prakashan, Pune.
5. Indian Pharmacopoeia, Ministry of Health and Family Welfare, Govt. of India, New Delhi. Wallis, T.E., Text Book of Pharmacognosy, Jand A Churchill Limited, London
BPharma, 5th (V) Sem PY-502 PHARMACEUTICS- VII  Syllabus  (DISPENSING, COMMUNITY AND HOSPITAL PHARMACY) Syllabus RGPV / RGTU B Pharma, PHARMACY 5th (V) Semester Syllabus

BPharma, 5th (V) Sem PY-502 PHARMACEUTICS- VII Syllabus (DISPENSING, COMMUNITY AND HOSPITAL PHARMACY) Syllabus RGPV / RGTU B Pharma, PHARMACY 5th (V) Semester Syllabus

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RGTU/RGPV PY-502 PHARMACEUTICS- VII  Syllabus 
RGTU/RGPV (DISPENSING, COMMUNITY AND HOSPITAL PHARMACY) Syllabus
BPharma 5th - Fifth Semester Syllabus

B. PHARMA- V SEMESTER (Modified on 14/06/10)
Effective for 2008 – 2009 Batch

PHARMACEUTICS- VII PY-502 (DISPENSING, COMMUNITY AND HOSPITAL PHARMACY) Course Contents:


 
Dispensing Pharmacy:
  • Prescription, Handling of prescription, Sources of errors in prescription, Care required in dispensing prescriptions. Brief introduction of commonly used Latin terms in prescription.
  • General Dispensing Procedures including labeling of dispensed products.
  • Principles involved and procedures adopted in dispensing of typical prescriptions- Powders, Solutions, Mixtures, Emulsions, Lotions & Liniments.
  • Physical, Chemical and Therapeutic incompatibilities, Incompatibility of common occurrence and their correction.
  • Basis of posology, Detection of over doses in prescription, knowledge of prophylactic and therapeutic doses with route of administration.
Community Pharmacy:
  • Organisation and structure of retail and wholesale drug stores, Legal requirements for establishment and maintenance. Dispensing of proprietary products, Maintenance of records of retail and wholesaler, Patient counseling, Role of Pharmacist in community health care and education, Hazards of medication.
  • A brief study of propritory products available in the market belonging to Chemotherapeutics, Vitamins, Anti-histaminics, expectorants and NSAID’S category.
Hospital Pharmacy:
  • Organization and structure: Organization of a hospital pharmacy, responsibilities of a hospital pharmacist, pharmacy and therapeutic committee.
  • Hospital Formulary: Contents, preparation and revision of hospital formulary.
LIST OF PRACTICALS:
1. Prepare and Dispense Simple Powder.
2. Prepare and Dispense Compound Powder.
3. Prepare and Dispense Powder containing small doses.
4. Prepare and Dispense Powder containing liquids.
5. Prepare and Dispense Powder containing liquefiable substances.
6. Prepare and Dispense Powder containing hygroscopic and deliquescent substances.
7. Prepare and Dispense Powder containing efflorescent materials.
8. Prepare and Dispense effervescent granules.
9. Prepare and Dispense Dusting Powder.
10. Prepare and Dispense Simple Mixture containing Soluble substances only.
11. Prepare and Dispense Mixture containing Diffusible solids.
12. Prepare and Dispense Mixture containing Indiffusible solids.
13. Prepare and Dispense Mixture containing Precipitate forming liquids.
14. Prepare and Dispense Mixture containing Slightly soluble liquids.
15. Prepare and Dispense Mixture containing Small doses of potent medicaments.
16. Prepare and Dispense prescription possessing Physical Incompability (Incomplete Solution).
17. Prepare and Dispense prescription possessing Physical Incompability (Precipitation).
18. Prepare and Dispense prescription possessing Physical Incompability (Separation of immiscible liquids).
19. Prepare and Dispense prescription possessing Chemical Incompability (Alkaloidal salts with alkaline substances).
20. Prepare and Dispense prescription possessing Chemical Incompability (Alkaloidal salts with soluble iodides).
21. Prepare and Dispense prescription possessing Chemical Incompability (Alkaloidal salts with salicylates).
22. Prepare and Dispense prescription possessing Chemical Incompability (Alkaloidal salts with benzoates).
23. Prepare and Dispense prescription possessing Chemical Incompability (Soluble salicylates with acids-Tolerated Incompatability).
24. Prepare and Dispense prescription possessing Chemical Incompability (Soluble salicylates with acids-Adjust Incompatability).
25. Prepare and Dispense prescription possessing Chemical Incompability (Soluble benzoates with acids-Tolerated Incompatability).
26. Prepare and Dispense prescription possessing Chemical Incompability (Soluble benzoates with acids-Adjusted Incompatability).
27. Prepare and Dispense prescription possessing Chemical Incompability (Soluble salicylates with ferric salts).
28. Prepare and Dispense prescription possessing Chemical Incompability (Soluble benzoates with ferric salts).
29. Prepare and Dispense prescription possessing Chemical Incompability (Evolution of carbon dioxide).
30. Prepare and Dispense prescription possessing Chemical Incompability of emulsifying agents. 
31. Prepare and Dispense Emulsion containing Volatile oils.
32. Prepare and Dispense Emulsion containing Fixed oils.
33. Prepare and Dispense Emulsion containing Oleoresins.
34. Prepare and Dispense Calamine lotion.
35. Prepare and Dispense turpentine liniment.

BOOKS RECOMMENDED:
1. Allwodd M. C. and Fell J. T., Text book of Hospital Pharmacy, Blackwell Scientific Publication, Oxford.
2. Hassan W. E., Lea and Febiger, Philadelphia Hospital Pharmacy.
3. J.S. Qadry, R.K. Goyal & R.K. Parika, Merchant & Qadry’s a text book of Hospital Pharmacy, B.S. Shah Prakashan, Ahmedabad.
4. Pratibha Nand & R.K. Khar, Text Book of Hospital & Clinical Pharmacy, Birla Publications Pvt Ltd., Delhi.
5. S.J. Carter (Ed.), Cooper & Gunn’s Dispensing for Pharmaceutical Students, CBS Publishers & Distributors, New Delhi.
6. R.M. Mehta, Dispensing Pharmacy, Vallabh Prakashan, Delhi. 
7. S.N. Sharma & N.K. Jain, the Concise Pharmaceutical Dispensing, Prakash B. Printers, Baroda.
8. N.K. Jain & G.D. Gupta, Modern Dispensing Pharmacy, PharmaMed Press, Hyderabad.
9. E.W. Martin, Dispensing of Medications (Formerly Husa’s Pharmaceutical Dispensing) Mack Publishing Company, Eastern Pa.
BPharma, 5th (V) Semester RGPV / RGTU PY-503 PHARMACEUTICAL CHEMISTRY -VI (MEDICINAL CHEMISTRY- I) Syllabus B Pharma, PHARMACY 5th (V) Semester Syllabus

BPharma, 5th (V) Semester RGPV / RGTU PY-503 PHARMACEUTICAL CHEMISTRY -VI (MEDICINAL CHEMISTRY- I) Syllabus B Pharma, PHARMACY 5th (V) Semester Syllabus

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RGTU/RGPV PY-503 PHARMACEUTICAL CHEMISTRY -VI Syllabus
BPharma 5th sem (MEDICINAL CHEMISTRY- I) Syllabus
BPharma 5th - Fifth Semester Syllabus


B. PHARMA- V SEMESTER (Modified on 14/06/10) Effective for 2008 – 2009 Batch

PY-503 PHARMACEUTICAL CHEMISTRY -VI (MEDICINAL CHEMISTRY- I) Course Contents:

Introduction to medicinal chemistry
  • Principles of drug discovery: Basic principles of medicinal chemistry, physicochemical and steric aspects (optical, geometric and bioisosterism) of drug molecules and biological actions.
  • Receptors and drug action: Receptor theories, affinity, receptor and biologic response.
  • Drug metabolism: Phase I (biotransformation reactions), phase II (conjugation reactions), factor affecting drug metabolism.
  • Prodrugs and drug latentiation: Basic concepts, prodrug of functional groups, bioprecursor  prodrugs, chemical delivery system.
Classification and mode of action, uses, structure activity relationship including  physicochemical, steric aspects and resents advances in research of the following categories of drugs:

Drugs affecting neurotransmission
  • Drugs affecting cholinergic neurotransmission: Neurochemistry and stereochemistry of  acetylcholine, acetylcholine mimetics-muscarinic agonists, acetlycholinesterase inhibitors, acetylcholine antagonists-muscarinic anatagonists, nicotinc antagonists-neuromuscular blocking agents, ganglionic blocking agents.
  • Drugs affecting adrenergic neurotransmission: Neurochemistry and stereochemistry of norepinephrine, sympathomimetic agents, sympatholytic agents, drugs affecting catecholamine biosynthesis, drugs affecting catecholamine storage and release, ergot alkaloids, xanthine bronchodilators
  • Drugs affecting serotonergic neurotransmission: Neurochemistry and stereochemistry of serotonin, 5-HT agonists, 5-HT antagonists.
  • Local anesthetics: Molecular mechanism of action, chemical aspects.
Drugs affecting immune systems
  • Non-steroidal anti-inflammatory agents: Chemistry of chemical mediators of inflammation (prostaglandins, thromboxanes, prostacyclin and leukotrienes), antipyretic analgesics.
  • Antihistaminics and related antiallergics: Neurochemistry and stereochemistry of histamine,
LIST OF PRACTICALS:
(Minimum fifteen experiments should be performed in the semester. Student should aware with safety parameters and handling of chemicals related to following experiments)
1. Synthesis and characteriazation of Tropenone from Maleyde aldehyde.
2. Synthesis and characteriazation of Scopolamine from Tropenol.
3. Synthesis and characterization of chlorzoxazone from 2-amino-4-chlorphenol.
4. Synthesis and characterization of Clemastine.
5. Synthesis and characterization of Tripelennamine.
6. Synthesis and characterization of Oxyphenbutazone.
7. Synthesis and characterization of trihexyl phenylidine.
8. Synthesis and characterization of Aspirin from salicylic acid.
9. Synthesis and characterization of Benzimadazole from benzyl chloride.
10. Synthesis and characterization of Sulphonilamide from Aniline.
11. Synthesis and characterization of Paracetamol from Para amino phenol.
12. Synthesis and characterization of Ibuprofen from isobutyl benzene.
13. Synthesis and characterization of Antipyrine
14. Synthesis and characterization of Phenyl benzoate.
15. Synthesis and characterization of Benzenilide.
16. Synthesis and characterization of Phenindione.
17. Synthesis and characterization of Methyl pyrazolone.

BOOKS RECOMMENDED:
1. Foye, W.C., Principles of Medicinal Chemistry, Lea and Febiger, Philadelphia.
2. Wolff , M.E. Ed., Burger’s Medicinal Chemistry, John Wiley and Sons, New York.
3. Hansch, C., Comprehensive Medicinal Chemistry, Pergarnon Press, Oxford.
4. Delagado, J.N. and Remers, W.A.R, Wilson and Giswold’s Text Book of Organic,Medicinal and Pharmaceutical Chemistry, J.Lippincott Co., Philadelphia.
5. Nogrady, T., Medicinal Chemistry-A Biochemical Approach, Oxford University Press, New York, Oxford.
6. Kar, A., Medicinal Chemistry, Willey Eastern Ltd., New Delhi.
7. Patrick, G., An Introduction to Medicinal Chemistry, Scientific Distributors, Mumbai.
8. Malone, Dyson and Purey, May’s Chemistry of Synthetic Drugs.
9. Parimoo, P., Text Book of Medicinal Chemistry, CBS Publishers and Distributors, New Delhi.
10. Thomas, G., Introduction to Medicinal Chemistry, CBS Publishers and Distributors, New Delhi.